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DateTitleAuthor(s)Full text
2004Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence: Platelet aggregation and relaxant activitiesAlexopoulos, K.; Fatseas, P.; Melissari, E.; Vlahakos, D.; Roumelioti, P.; Mavromoustakos, Thomas; Mihailescu, S.; Paredes-Carbajal, M. C.; Mascher, D.; Matsoukas, J.
2001Design, synthesis, and modeling of novel cyclic thrombin receptor-derived peptide analogues of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence with fixed conformations of pharmacophoric groups: Importance of a Phe/Arg/NH2 cluster for receptor activation and implications in the design of nonpeptide thrombin receptor mimeticsAlexopoulos, K.; Panagiotopoulos, D.; Mavromoustakos, Thomas; Fatseas, P.; Paredes-Carbajal, M. C.; Mascher, D.; Mihailescu, S.; Matsoukas, J.
2000Structural comparison between type I and type II antagonists: Possible implications in the drug design of AT1 antagonistsRoumelioti, P.; Tselios, T.; Alexopoulos, K.; Mavromoustakos, Thomas; Kolocouris, A.; Moore, G. J.; Matsoukas, J. M.
1999Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffoldAlexopoulos, K.; Fatseas, P.; Melissari, E.; Vlahakos, D.; Smith, J.; Mavromoustakos, Thomas; Saifeddine, M.; Moore, G.; Hollenberg, M.; Matsoukas, J.
1998A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activityAlexopoulos, K.; Matsoukas, J.; Tselios, T.; Roumelioti, P.; Mavromoustakos, Thomas; Holada, K.
1998A comparative SAR study of thrombin receptor derived non peptide mimetics: Importance of phenyl/guanidino proximity for activityAlexopoulos, K.; Matsoukas, J.; Tselios, T.; Roumelioti, P.; Mavromoustakos, Thomas; Holada, K.
1997Use of molecular modeling to study superimposition of the thrombin receptor motif S42FLLR46 with its peptidomimetic analogsMavromoustakos, Thomas; Theodoropoulou, E.; Alexopoulos, K.; Matsoukas, J.; Hollenberg, M.; Moore, G. J.
1996Synthesis and activities of cyclic thrombin-receptor-derived peptide analogues of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence containing D-Phe and/or D-ArgPanagiotopoulos, D.; Matsoukas, J. M.; Alexopoulos, K.; Zebeki, A.; Mavromoustakos, Thomas; Saifeddine, M.; Hollenberg, M. D.
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