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DateTitleAuthor(s)Full text
2006Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside siteHampson, L. J.; Arden, C.; Agius, L.; Ganotidis, M.; Kosmopoulou, M. N.; Tiraidis, C.; Elemes, Y.; Sakarellos, C.; Leonidas, Demetres D.; Oikonomakos, Nikos G.
2006Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylaseAnagnostou, E.; Kosmopoulou, M. N.; Chrysina, Evangelia D.; Leonidas, D. D.; Hadjiloi, T.; Tiraidis, C.; Zographos, S. E.; Gyorgydeak, Z.; Somsak, L.; Docsa, T.; Gergely, P.; Kolisis, Fragiskos N.; Oikonomakos, Nikos G.
2005Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugsOikonomakos, Nikos G.; Kosmopoulou, M. N.; Chrysina, Evangelia D.; Leonidas, Demetres D.; Kostas, Ioannis D.; Wendt, K. U.; Klabunde, T.; Defossa, E.
2005Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studiesChrysina, Evangelia D.; Kosmopoulou, M. N.; Kardakaris, R.; Bischler, N.; Leonidas, Demetres D.; Kannan, T.; Loganathan, D.; Oikonomakos, Nikos G.
2005Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1,3,4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding siteChrysina, Evangelia D.; Kosmopoulou, M. N.; Tiraidis, C.; Kardakaris, R.; Bischler, N.; Leonidas, Demetres D.; Hadady, Z.; Somsak, L.; Docsa, T.; Gergely, P.; Oikonomakos, Nikos G.
2005Indirubin-3 '-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sitesKosmopoulou, M. N.; Leonidas, Demetres D.; Chrysina, Evangelia D.; Eisenbrand, G.; Oikonomakos, Nikos G.
2005Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetesKlabunde, T.; Wendt, K. U.; Kadereit, D.; Brachvogel, V.; Burger, H. J.; Herling, A. W.; Oikonomakos, Nikos G.; Kosmopoulou, M. N.; Schmoll, D.; Sarubbi, E.; von Roedern, E.; Schonafinger, K.; Defossa, E.
2004Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b - Comparison with ligand binding to pCDK2-cyclin A complexKosmopoulou, M. N.; Leonidas, Demetres D.; Chrysina, Evangelia D.; Bischler, N.; Eisenbrand, G.; Sakarellos, C. E.; Pauptit, R.; Oikonomakos, Nikos G.
2003Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 angstrom resolutionOikonomakos, Nikos G.; Chrysina, Evangelia D.; Kosmopoulou, M. N.; Leonidas, Demetres D.
2003Crystallization and preliminary X-ray crystallographic analysis of Sclerotium rolfsii lectinLeonidas, Demetres D.; Swamy, B. M.; Bhat, A. G.; Inamdar, S. R.; Kosmopoulou, M. N.; Chrysina, Evangelia D.; Oikonomakos, Nikos G.
2003Crystallographic studies on alpha- and beta-D-glucopyranosyl formamide analogues, inhibitors of glycogen phosphorylaseChrysina, Evangelia D.; Oikonomakos, Nikos G.; Zographos, Spyros E.; Kosmopoulou, M. N.; Bischler, N.; Leonidas, Demetres D.; Kovacs, L.; Docsa, T.; Gergely, P.; Somsak, L.
2003High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitorsLeonidas, Demetres D.; Chavali, G. B.; Oikonomakos, Nikos G.; Chrysina, Evangelia D.; Kosmopoulou, M. N.; Vlassi, M.; Frankling, C.; Acharya, K. R.
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