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DateTitleAuthor(s)Full text
2007Structure-based design of inhibitors of glycogenolysis, as a promising therapeutic strategy in the treatment of type 2 diabetesOikonomakos, Nikos G.
2007In the search of glycogen phosphorylase inhibitors: 4. Synthesis of C-D-glycopyranosylbenzo(hydro)quinones - Inhibition of and binding to glycogen phosphorylase in the crystalHe, L.; Zhang, Y. Z.; Tanoh, M.; Chen, G. R.; Praly, J. P.; Chrysina, Evangelia D.; Tiraidis, C.; Kosmopoulou, M.; Leonidas, Demetres D.; Oikonomakos, Nikos G.
2007Structural basis for the carbohydrate recognition of the Sclerotium rolfsii lectinLeonidas, Demetres D.; Swamy, B. M.; Hatzopoulos, G. N.; Gonchigar, S. J.; Chachadi, V. B.; Inamdar, S. R.; Zographos, Spyros E.; Oikonomakos, Nikos G.
2006Binding of oxalyl derivatives of beta-D-glucopyranosylamine to muscle glycogen phosphorylase bHadjiloi, T.; Tiraidis, C.; Chrysina, Evangelia D.; Leonidas, Demetres D.; Oikonomakos, Nikos G.; Tsipos, P.; Gimisis, T.
2006Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylaseAnagnostou, E.; Kosmopoulou, M. N.; Chrysina, Evangelia D.; Leonidas, D. D.; Hadjiloi, T.; Tiraidis, C.; Zographos, S. E.; Gyorgydeak, Z.; Somsak, L.; Docsa, T.; Gergely, P.; Kolisis, Fragiskos N.; Oikonomakos, Nikos G.
2006Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside siteHampson, L. J.; Arden, C.; Agius, L.; Ganotidis, M.; Kosmopoulou, M. N.; Tiraidis, C.; Elemes, Y.; Sakarellos, C.; Leonidas, Demetres D.; Oikonomakos, Nikos G.
2006Crystallographic studies on N-azidoacetyl-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-beta-D-glucopyranosylaminePetsalakis, E. I.; Chrysina, Evangelia D.; Tiraidis, C.; Hadjiloi, T.; Leonidas, Demetres D.; Oikonomakos, Nikos G.; Aich, U.; Varghese, B.; Loganathan, D.
2006Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studiesWhittamore, P. R. O.; Addie, M. S.; Bennett, S. N. L.; Birch, A. M.; Butters, M.; Godfrey, L.; Kenny, P. W.; Morley, A. D.; Murray, P. M.; Oikonomakos, Nikos G.; Otterbein, L. R.; Pannifer, A. D.; Parker, J. S.; Readman, K.; Siedlecki, P. S.; Schofield, P.; Stocker, A.; Taylor, M. J.; Townsend, L. A.; Whalley, D. P.; Whitehouse, J.
2006Indirubin and indigo analogues as potential inhibitors of glycogenolysis: structural basis of glycogen phosphorylase inhibitionOikonomakos, Nikos G.; Kosmopoulou, Magda N.; Leonidas, Demetres D.; Chrysina, Evangelia D.; Tiraidis, Costas; Bischler, Nicolas; Tsitsanou, Katerina E.; Zographos, Spyros E.; Kostas, Ioannis D.; Eisenbrand, Gerhard
2006The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T-State and R-State featuresLukacs, C. M.; Oikonomakos, Nikos G.; Crowther, R. L.; Hong, L. N.; Kammlott, R. U.; Levin, W.; Li, S.; Liu, C. M.; Lucas-McGady, D.; Pietranico, S.; Reik, L.
2006Iminosugars as potential inhibitors of glycogenolysis: Structural insights into the molecular basis of glycogen phosphorylase inhibitionOikonomakos, Nikos G.; Tiraidis, C.; Leonidas, Demetres D.; Zographos, Spyros E.; Kristiansen, M.; Jessen, C. U.; Norskov-Lauritsen, L.; Agius, L.
2006The binding of 3 '-N-piperidine-4-carboxyl-3 '-deoxy-ara-uridine to ribonuclease A in the crystalLeonidas, Demetres D.; Maiti, T. K.; Samanta, A.; Dasgupta, S.; Pathak, T.; Zographos, Spyros E.; Oikonomakos, Nikos G.
2005Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylaseWatson, K. A.; Chrysina, Evangelia D.; Tsitsanou, K. E.; Zographos, Spyros E.; Archontis, G.; Fleet, G. W. J.; Oikonomakos, Nikos G.
2005The binding of IMP to ribonuclease AHatzopoulos, G. N.; Leonidas, Demetres D.; Kardakaris, R.; Kobe, J.; Oikonomakos, Nikos G.
2005Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analoguesArchontis, G.; Watson, K. A.; Xie, Q.; Andreou, G.; Chrysina, Evangelia D.; Zographos, Spyros E.; Oikonomakos, Nikos G.; Karplus, M.
2005Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetesKlabunde, T.; Wendt, K. U.; Kadereit, D.; Brachvogel, V.; Burger, H. J.; Herling, A. W.; Oikonomakos, Nikos G.; Kosmopoulou, M. N.; Schmoll, D.; Sarubbi, E.; von Roedern, E.; Schonafinger, K.; Defossa, E.
2005Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugsOikonomakos, Nikos G.; Kosmopoulou, M. N.; Chrysina, Evangelia D.; Leonidas, Demetres D.; Kostas, Ioannis D.; Wendt, K. U.; Klabunde, T.; Defossa, E.
2005Indirubin-3 '-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sitesKosmopoulou, M. N.; Leonidas, Demetres D.; Chrysina, Evangelia D.; Eisenbrand, G.; Oikonomakos, Nikos G.
2005Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studiesChrysina, Evangelia D.; Kosmopoulou, M. N.; Kardakaris, R.; Bischler, N.; Leonidas, Demetres D.; Kannan, T.; Loganathan, D.; Oikonomakos, Nikos G.
2005Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1,3,4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding siteChrysina, Evangelia D.; Kosmopoulou, M. N.; Tiraidis, C.; Kardakaris, R.; Bischler, N.; Leonidas, Demetres D.; Hadady, Z.; Somsak, L.; Docsa, T.; Gergely, P.; Oikonomakos, Nikos G.
Showing results 21 to 40 of 110

 

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