Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Estrogen receptor a and beta in uterine fibroids: a basis for altered estrogen responsiveness
Δημιουργός/Συγγραφέας:	Bakas, Panagiotis Liapis, Angelos Vlahopoulos, Spiros Giner, Maria Logotheti, Stella Creatsas, Georgios Meligova, Aggeliki K. [EL] Αλέξης, Μιχαήλ Ν.[EN] Alexis, Michael N. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Εκδότης:	Elsevier Science Incorporated
Τόπος έκδοσης:	New York
Ημερομηνία:	2008-11
Γλώσσα:	Αγγλικά
ISSN:	0015-0282
DOI:	10.1016/j.fertnstert.2007.09.019
Περίληψη:	Objective: To investigate the relative expression and the DNA-binding status of estrogen receptors alpha and beta in fibroids and normal myometrial tissue to explore the molecular basis of altered estrogen responsiveness of leiomyomas. Design: Biopsy samples from uterine fibroids and adjacent normal myometrial tissue at the follicular phase of the menstrual cycle. Setting: Aretaieio University Hospital and the National Hellenic Research Foundation, Athens, Greece. Patient(S): Thirty-five patients who underwent hysterectomy or myomectomy because of myoma symptoms. Intervention(S): None. Main Outcome Measure(s): Deoxyribonucleic acid-binding status of estrogen receptors alpha and beta. Result(s): The level of messenger RNA expression of estrogen receptor alpha and beta and the level of estrogen receptor as a whole are increased on average to a similar extent in leiomyomas compared with normal myometrium. Occasionally, however, estrogen receptor alpha is disproportionately increased in leiomyomas, and this appears to increase the amount of estrogen receptor alpha that binds to the estrogen-responsive element of estrogen target genes as homodimer rather than as heterodimer with estrogen receptor beta. Conclusion(s): The estrogen receptor alpha-to-estrogen receptor beta expression ratio rather than the individual expression levels determines the fraction of DNA-binding homodimers of estrogen receptor alpha and possibly the growth potential of myomas.
Τίτλος πηγής δημοσίευσης:	Fertility and Sterility
Τόμος/Κεφάλαιο:	90
Τεύχος:	5
Σελίδες:	1878-1885
Θεματική Κατηγορία:	[EL] Μαιευτική και γυναικολογία[EN] Gynecology and obstetrics [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Uterine myomas estrogen receptor alpha estrogen receptor beta myometrium fibroids
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2008 by American Society for Reproductive Medicine.)
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.sciencedirect.com/science/journal/00150282
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο