Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The Proteasome Is an Integral Part of Solar Ultraviolet A Radiation-induced Gene Expression
Δημιουργός/Συγγραφέας:	Catalgol, Betul Ziaja, Isabella Breusing, Nicolle Jung, Tobias Hoehn, Annika Alpertunga, Buket Schroeder, Peter [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Petropoulos, Isabelle Friguet, Bertrand Klotz, Lars-Oliver Krutmann, Jean Grune, Tilman
Εκδότης:	American Society for Biochemistry and Molecular Biology, Inc.
Τόπος έκδοσης:	BETHESDA
Ημερομηνία:	2009-10-30
Γλώσσα:	Αγγλικά
ISSN:	0021-9258
DOI:	10.1074/jbc.M109.044503
Περίληψη:	Solar ultraviolet (UV) A radiation is a well known trigger of signaling responses in human skin fibroblasts. One important consequence of this stress response is the increased expression of matrix metalloproteinase-1 (MMP-1), which causes extracellular protein degradation and thereby contributes to photoaging of human skin. In the present study we identify the proteasome as an integral part of the UVA-induced, intracellular signaling cascade in human dermal fibroblasts. UVA-induced singlet oxygen formation was accompanied by protein oxidation, the cross-linking of oxidized proteins, and an inhibition of the proteasomal system. This proteasomal inhibition subsequently led to an accumulation of c-Jun and phosphorylated c-Jun and activation of activator protein-1, i.e. transcription factors known to control MMP-1 expression. Increased transcription factor activation was also observed if the proteasome was inhibited by cross-linked proteins or lactacystin, indicating a general mechanism. Most importantly, inhibition of the proteasome was of functional relevance for UVA-induced MMP-1 expression, because overexpression of the proteasome or the protein repair enzyme methionine sulfoxide reductase prevented the UVA-induced induction of MMP-1. These studies show that an environmentally relevant stimulus can trigger a signaling pathway, which links intracellular and extracellular protein degradation. They also identify the proteasome as an integral part of the UVA stress response.
Τίτλος πηγής δημοσίευσης:	Journal of Biological Chemistry
Τόμος/Κεφάλαιο:	284
Τεύχος:	44
Σελίδες:	30076-30086
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.jbc.org/
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο