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|Title:||9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini|
Abdel-Razik, Ayman F.
Alexis, Michael N.
|Type:||Journal Article (Scientific Journal article)|
|Abstract:||Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells.|
|Journal Title:||Bioorganic & Medicinal Chemistry|
|Subject Category:||Science::Biology (General)|
Medicine::Pharmacy and materia medica
|Keywords:||Eunicella cavolini; 9,11-Secosterols; Structure elucidation; Antiproliferative activity; Chemistry, Medicinal|
|Other Identifiers:||DOI: http://dx.doi.org/10.1016/j.bmc.2009.05.004|
|Journal web Location :||http://www.elsevier.com/locate/bmc|
|Rights holder:||© 2009 Elsevier Ltd. All rights reserved.|