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|Title:||5 alpha,8 alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity|
Abdel-Razik, Ayman F.
Alexis, Michael N.
|Type:||Journal Article (Scientific Journal article)|
|Abstract:||Three new (1, 4, 9) and nine previously reported (2, 3, 5-8, 10-12) 5 alpha,8 alpha-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1-12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1-12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity.|
|Publication Place:||NEW YORK|
|Subject Category:||Science::Biology (General)|
|Keywords:||Eunicella cavolini; Trididemnum inarmatum; 5 alpha,8 alpha-Epidioxysterols; Structure elucidation; Antiproliferative activity; Endocrinology & Metabolism|
|Other Identifiers:||DOI: http://dx.doi.org/10.1016/j.steroids.2008.09.007|
|Journal web Location :||http://www.elsevier.com/locate/steroids|
|Rights holder:||© 2008 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Institute of Biological Research and Biotechnology (IBRB) (until 2012)|
Institute of Organic and Pharmaceutical Chemistry (IOPC) (until 2012)