The full text of this item is not currently available in HELIOS
|Title:||Dietary acrylamide intake and risk of breast cancer in the UK women's cohort|
|Author/Creator:||Burley, V. J.|
Greenwood, D. C.
Hepworth, S. J.
Fraser, L. K.
de Kok, T. M.
van Breda, S. G.
Kyrtopoulos, S. A.
McKinney, P. A.
Cade, J. E.
|Type:||Journal Article (Scientific Journal article)|
|Abstract:||BACKGROUND: No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide. METHODS: A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33 731 women aged 35-69 years from the UK Women's Cohort Study followed up for a median of 11 years. RESULTS: In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio = 1.08 per 10 mu g day(-1), 95% CI: 0.98-1.18, P(trend) = 0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio - 1.2, 95% CI: 1.0-1.3, P(trend) = 0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio = 1.0, 95% CI: 0.9-1.1, P(trend) = 0.99). CONCLUSIONS: There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation.|
|Publisher:||Nature Publishing Group|
|Journal Title:||British Journal of Cancer|
|Subject Category:||Medicine::Internal medicine::Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)|
|Keywords:||cohort study; acrylamide; diet; breast cancer|
|Other Identifiers:||DOI: http://dx.doi.org/10.1038/sj.bjc.6605956|
|Journal web Location :||http://www.nature.com/bjc|
|Rights holder:||© 2010 Cancer Research UK|