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|Title:||Global DNA hypomethylation-induced Delta Np73 transcriptional activation in non-small cell lung cancer|
Gosney, John R.
Kastania, Anastasia N.
Field, John K.
|Type:||Journal Article (Scientific Journal article)|
|Abstract:||p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the anti-apoptotic Delta Np73 isoforms respectively In this study we investigated the DNA methylation status of both promoters as a means of epigenetic transcriptional control of their corresponding isoforms in 102 primary non-small cell lung carcinomas (NSCLCs) We demonstrated that while P1 hypermethylation-associated reduction of TAp73 mRNA levels is relatively infrequent the P2 hypomethylation-associated over-expression of Delta Np73 mRNA is a frequent event particularly among squamous cell carcinomas P2 hypomethylation strongly correlated with LINE-1 element hypomethylation indicating that Delta Np73 over-expression may be a passive consequence of global DNA hypomethylation|
|Publisher:||Elsevier Ireland Limited|
|Journal Title:||Cancer Letters|
|Subject Category:||Medicine::Internal medicine::Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)|
|Keywords:||Lung cancer; p73; DNA methylation; Delta Np73; TAp73|
|Other Identifiers:||DOI: http://dx.doi.org/10.1016/j.canlet.2010.09.009|
|Journal web Location :||http://www.elsevier.com/locate/canlet|
|Rights holder:||© 2010 Elsevier Ireland Ltd All rights reserved|