Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Dendrimers as biopharmaceuticals: Synthesis and properties
Δημιουργός/Συγγραφέας:	[EL] Βιλλιαλονγκα-Μπαρμπέρ, Καρολίνα[EN] Villalonga-Barber, Carolina [EL] Μίχα-Σκρέττα, Μαρία[EN] Micha-Screttas, Maria [EL] Στηλ, Μπάρυ[EN] Steele, Barry R. Georgopoulos, Aristidis Demetzos, Costas
Εκδότης:	Bentham Science Publishers Ltd.
Τόπος έκδοσης:	SHARJAH
Ημερομηνία:	2008-09
Γλώσσα:	Αγγλικά
ISSN:	1568-0266
DOI:	10.2174/156802608785849012
Περίληψη:	Two general aspects which need to be considered for the successful application of dendrimers for biomedical purposes are their availability at an acceptable cost and their suitability as regards their pharmacodynamic and pharmacokinetic properties. These two aspects are covered in this review. In the first part, synthetic strategies for the preparation of dendrimers are outlined and emphasis is given to recent work on methodologies whose aim is the development of more efficient routes to dendrimers in terms of the materials used for their synthesis as well as in terms of the procedures required for their purification. These include procedures involving double-stage and double exponential synthesis, orthogonal coupling strategies, self-assembly and solid-phase approaches, as well as particularly useful synthetic protocols such as those used in "click chemistry". The second part of the review deals with the way in which the size, chemical constitution and physicochemical properties of dendrimers used for drug delivery may affect pharmacodynamic and pharmacokinetic parameters which are important considerations for drug bioavailability. This is illustrated by an overview of examples from recent work involving non-steroidal anti-inflammatory drugs, anticancer drugs and antibacterials.
Τίτλος πηγής δημοσίευσης:	Current Topics in Medicinal Chemistry
Τόμος/Κεφάλαιο:	8
Τεύχος:	14
Σελίδες:	1294-1309
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Φαρμακευτική[EN] Pharmacy and materia medica
Λέξεις-Κλειδιά:	dendrimer synthesis double-stage synthesis double exponential synthesis orthogonal coupling lego chemistry click chemistry self-assembly solid-phase synthesis pharmacodynamics pharmacokinetics Chemistry, Medicinal
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© BENTHAM SCIENCE PUBL LTD
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.bentham.org/ctmc
Σημειώσεις:	Review
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο