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|Title:||Peptidomimetic-functionalized carbon nanotubes with antitrypsin activity|
Papi, Rigini M.
Kyriakidis, Dimitrios A.
|Type:||Journal Article (Scientific Journal article)|
|Abstract:||Water-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics. The structural design of the covalently grafted peptidomimetics to the CNTs is based on their structural similarity with the metabolites of antagonist G of substance P. A variety of analytical spectroscopic methods, in combination with electron microscopy and thermal analysis, aided the structural and morphological characterization of the four newly synthesized peptidomimetic-CNT conjugates. It is demonstrated that the trypsin inhibitory effect of the peptidomimetic-CNT is enhanced as a result of the high-loading of peptidomimetics onto the skeleton of the modified water-soluble CNTs. Additionally, the peptidomimetic-functionalized CNT conjugates can be recovered and re-employed up to six biological evaluation cycles showing the same trypsin inhibitory activity Such a nanosized system is extremely advantageous for the inhibition of inflammation or malignancy and could find potential future biological applications in the area of drug delivery systems.|
|Subject Category:||Science::Chemistry (General)|
|Keywords:||Chemistry, Physical; Materials Science, Multidisciplinary|
|Other Identifiers:||DOI: http://dx.doi.org/10.1016/j.carbon.2009.08.025|
|Journal web Location :||http://www.elsevier.com/locate/carbon|
|Rights holder:||© 2009 Elsevier Ltd. All rights reserved.|
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