Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Advanced nanocarriers for an antitumor peptide
Δημιουργός/Συγγραφέας:	Pippa N. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C. Sivolapenko G.
Εκδότης:	Kluwer Academic Publishers
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	1388-0764
DOI:	10.1007/s11051-013-2062-y
Περίληψη:	In this work, tigapotide (PCK3145) was incorporated into novel nanocarriers based on polymeric, lipidic, and dendrimeric components, in order to maximize the advantages of the drug delivery process and possibly its biological properties. PCK3145 was incorporated into lipidic nanocarriers composed of Egg phosphatidylcholine (EggPC) and dipalmytoylphosphatidylcholine (DPPC) (EggPC:PCK3145 and DPPC: PCK3145, 9:0.2 molar ratio), into cationic liposomes composed of EggPC:SA:PCK3145 and DPPC:SA:PCK 3145 (9:1:0.2 molar ratio) into complexes with the block polyelectrolyte (quaternized poly[3,5- bis(dimethylaminomethylene) hydroxystyrene]-b-poly(ethylene oxide) (QNPHOSEO) and finally into dendrimeric structures (i.e., PAMAMG4). Light scattering techniques are used in order to examine the size, the size distribution and the Z-potential of the nanocarriers in aqueous and biological media. Fluorescence spectroscopy was utilized in an attempt to extract information on the internal nanostructure and microenvironment of polyelectrolyte/PCK3145 aggregates. Therefore, these studies could be a rational roadmap for producing various effective nanocarriers in order to ameliorate the pharmacokinetic behavior and safety issues of antitumor and anticancer biomolecules.
Τίτλος πηγής δημοσίευσης:	Journal of Nanoparticle Research
Τόμος/Κεφάλαιο:	15
Τεύχος:	11
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Block polyelectrolyte Dendrimers Drug delivery Liposomes Nanomedicine Tigapotide
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© Springer Science+Business Media 2013.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	European Commission, EC; European Social Fund, ESF Authors acknowledge financial support of the work by the NANOMACRO 1129 project which is implemented in the framework of the Operational Program ‘‘Education and Life-long Learning’’ (Action ‘‘ARISTEIA I’’)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο