Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study
Δημιουργός/Συγγραφέας:	Rietman M.L. Spijkerman A.M.W. Wong A. van Steeg H. Bürkle A. Moreno-Villanueva M. Sindlinger T. Franceschi C. Grubeck-Loebenstein B. Bernhardt J. Slagboom P.E. Toussaint O. Debacq-Chainiaux F. Sikora E. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Breusing N. Stuetz W. Weber D. Grune T. Basso A. Piacenza F. Malavolta M. Collino S. Jansen E.H.J.M. Verschuren W.M.M. Dollé M.E.T.
Εκδότης:	Elsevier Ireland Ltd
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	0047-6374
DOI:	10.1016/j.mad.2018.04.007
Άλλο:	PubMed ID: 29719199
Περίληψη:	Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i.e. biomarkers and markers, for the physical, cognitive, and psychological frailty domains. We used univariate (Rank-ANOVA) and multivariate (elastic net) approaches on the RASIG study population (age range: 35–74 years, n = 2220) of the MARK-AGE study to study up to 331 (bio)markers between individuals with and without frailty for each domain. Biomarkers and markers identified by both approaches were studied further regarding their association with frailty using logistic regression. Univariately, we found lower levels of antioxidants, including β-cryptoxanthin and zeaxanthin, in those who were physically, cognitively or psychologically frail. Additionally, self-reported health was worse in these three frail groups. Multivariately, we observed lower levels of β-cryptoxanthin and zeaxanthin in the cognitively frail. Levels of these carotenoids were inversely associated with the risk of being cognitively frail after adjusting for confounders. Antioxidants and self-reported health are potential (bio)markers to detect persons at risk of becoming frail. The biomarkers identified may indicate the involvement of inflammation in frailty, especially for physical and cognitive frailty.
Τίτλος πηγής δημοσίευσης:	Mechanisms of Ageing and Development
Τόμος/Κεφάλαιο:	177
Σελίδες:	135-143
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Ageing Elastic net Frailty Machine learning Multidimensional Multivariate Univariate
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	S132002; Seventh Framework Programme, FP7; European Commission, EC; Ministerie van Volksgezondheid, Welzijn en Sport, VWS; Seventh Framework Programme, FP7: 200880. This work was supported by the Ministry of Health, Welfare and Sport of the Netherlands, the National Institute for Public Health and the Environment (grant number S132002 ) and the European Commission through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement No.: 200880 ). This work was supported by the Ministry of Health, Welfare and Sport of the Netherlands, the National Institute for Public Health and the Environment (grant number S132002) and the European Commission through the FP7 large-scale integrating project ?European Study to Establish Biomarkers of Human Ageing? (MARK-AGE; grant agreement No.: 200880).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο