Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Reliable but timesaving: In search of an efficient quantum-chemical method for the description of functional fullerenes
Δημιουργός/Συγγραφέας:	[EL] Ραϊς, Χεριμπέρτ[EN] Reis, Heribert Rasulev B. [EL] Παπαδόπουλος, Μάνθος Γ.[EN] Papadopoulos, Manthos G. Leszczynski J.
Εκδότης:	Bentham Science Publishers B.V.
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	1568-0266
DOI:	10.2174/1568026615666150506150601
Άλλο:	PubMed ID: 25961522
Περίληψη:	Fullerene and its derivatives are currently one of the most intensively investigated species in the area of nanomedicine and nanochemistry. Various unique properties of fullerenes are responsible for their wide range applications in industry, biology and medicine. A large pool of functionalized C60 and C70 fullerenes is investigated theoretically at different levels of quantum-mechanical theory. The semiempirial PM6 method, density functional theory with the B3LYP functional, and correlated ab initio MP2 method are employed to compute the optimized structures, and an array of properties for the considered species. In addition to the calculations for isolated molecules, the results of solution calculations are also reported at the DFT level, using the polarizable continuum model (PCM). Ionization potentials (IPs) and electron affinities (EAs) are computed by means of Koopmans’ theorem as well as with the more accurate but computationally expensive ΔSCF method. Both procedures yield comparable values, while comparison of IPs and EAs computed with different quantum-mechanical methods shows surprisingly large differences. Harmonic vibrational frequencies are computed at the PM6 and B3LYP levels of theory and compared with each other. A possible application of the frequencies as 3D descriptors in the EVA (EigenVAlues) method is shown. All the computed data are made available, and may be used to replace experimental data in routine applications where large amounts of data are required, e.g. in structure-activity relationship studies of the toxicity of fullerene derivatives.
Τίτλος πηγής δημοσίευσης:	Current Topics in Medicinal Chemistry
Τόμος/Κεφάλαιο:	15
Τεύχος:	18
Σελίδες:	1845-1858
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	B3LYP Eigenvalue Electron affinity Fullerene Ionization potential MP2 PCM PM6
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 Bentham Science Publishers.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο