Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Proteasome activation delays aging in vitro and in vivo
Δημιουργός/Συγγραφέας:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Sakellari M. Lefaki M. Papaevgeniou N. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Εκδότης:	Elsevier Inc.
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	0891-5849
DOI:	10.1016/j.freeradbiomed.2014.03.031
Άλλο:	PubMed ID: 24681338
Περίληψη:	Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded, or aggregated proteins. In particular, the proteasome is responsible for the removal of normal as well as damaged or misfolded proteins. Extensive work during the past several years has clearly demonstrated that proteasome activation by either genetic means or use of compounds significantly retards aging. Importantly, this represents a common feature across evolution, thereby suggesting proteasome activation to be an evolutionarily conserved mechanism of aging and longevity regulation. This review article reports on the means of function of these proteasome activators and how they regulate aging in various species.
Τίτλος πηγής δημοσίευσης:	Free Radical Biology and Medicine
Τόμος/Κεφάλαιο:	71
Σελίδες:	303-320
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Aging Free radicals Longevity regulation Proteasome activation Senescence Ubiquitin-proteasome system
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 Elsevier Inc.
Σημειώσεις:	European Social Fund, ESF: 11ΣΥΝ_1_1112; European Commission, EC; European Cooperation in Science and Technology, COST: BM1203, CM1001. Cited work from our laboratories was funded by a research funding program, Thales “GenAge” to E.S.G. and N.C. and Thales “Maestro” to N.C., cofinanced by the European Union (European Social Fund) and Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework; a SYNERGASIA project (11ΣΥΝ_1_1112) and a KRIPIS project to E.S.G. and N.C.; an IKYDA 2012 fellowship and a Scientific Project funded by the John S. Latsis Public Benefit Foundation to N.C.; an EU COST CM1001 grant to E.S.G. and N.C.; and an EU COST BM1203 grant to N.C.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο