Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	pH-responsive chimeric liposomes: From nanotechnology to biological assessment
Δημιουργός/Συγγραφέας:	Naziris, Nikolaos Saitta, Francesca Chrysostomou, Varvara Libera, Marcin Trzebicka, Barbara Fessas, Dimitrios [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos, Costas
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2020-01-25
Γλώσσα:	Αγγλικά
ISSN:	03785173
DOI:	10.1016/j.ijpharm.2019.118849
Άλλο:	31759108
Περίληψη:	The utilization of liposomes in biomedical applications has greatly benefited the diagnosis and treatment of various diseases. These biomimetic nano-entities have been very useful in the clinical practice as drug delivery systems in their conventional form, comprising lipids as structural components. However, the scientific efforts have recently shifted towards the development of more sophisticated nanotechnological platforms, which apply functional biomaterials, such as stimuli-responsive polymers, in order to aid the drug molecule targeting concept. These nanosystems are defined as chimeric/mixed, because they combine more than one different in nature biomaterials and their development requires intensive study through biophysical and thermodynamic approaches before they may reach in vivo application. Herein, we designed and developed chimeric liposomes, composed of a phospholipid and pH-responsive amphiphilic diblock copolymers and studied their morphology and behavior based on crucial formulation parameters, including biomaterial concentration, dispersion medium pH and polymer composition. Additionally, their interactions with biological components, pH-responsiveness and membrane thermodynamics were assessed. Finally, preliminary in vivo toxicity experiments of the developed nanosystems were carried out, in order to establish a future protocol for full in vivo evaluation. The results have been correlated with the properties of the chimeric nanosystems and highlight the importance of such approaches for designing and developing effective nanocarriers for biomedical applications.
Τίτλος πηγής δημοσίευσης:	International journal of pharmaceutics
Τόμος/Κεφάλαιο:	574
Σελίδες:	118849
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Ιατρική[EN] Medicine [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Chimeric liposomes Interactions Lyotropism Micro-DSC pH-responsive Animals Drug Carriers Drug Delivery Systems Hydrogen-Ion Concentration Liposomes Male Mice Mice, Inbred NOD Mice, SCID Nanoparticles Nanotechnology Phospholipids Polymers
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2019 Elsevier B.V. All rights reserved
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/abs/pii/S0378517319308944?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/international-journal-of-pharmaceutics
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο