Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Poly(2‐[dimethylamino]ethyl methacrylate)‐b‐poly(hydroxypropyl methacrylate)/DNA polyplexes in aqueous solutions
Δημιουργός/Συγγραφέας:	Sentoukas, Theodore [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Wiley
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISSN:	2642-4150 2642-4169
DOI:	10.1002/pol.20200375
Περίληψη:	This study involves the investigation of the complexation ability of poly(2-[dimethylamino]ethyl methacrylate)-b-poly(hydroxypropyl methacrylate) (PDMAEMA-b-PHPMA) amphiphilic pH and thermoresponsive block copolymers, and their quaternized counterparts QPDMAEMA-b-PHPMA, toward short DNA in aqueous solutions. The PDMAEMA-b-PHPMA amphiphilic block copolymers present various self-assembly characteristics when inserted into aqueous media, depending on the composition, the solubilization protocol, the acidity and the temperature of the aqueous media. Copolymer aggregates-DNA interactions and nanostructure formation after complexation are investigated by dynamic light scattering and intensity measurements in aqueous solutions in a fixed temperature range, utilizing two different solubilization protocols for the copolymers. Ethidium bromide assays by fluorescence spectroscopy and ζ-potential measurements were also utilized to investigate the structure and properties of the DNA/copolymer polyplexes. The interpretation of such physicochemical characterization provides extra comprehension of the novel (Q)PDMAEMA-b-PHPMA copolymers self-assembly characteristics and assesses their ability for DNA complexation, stabilization, and delivery.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science
Τόμος/Κεφάλαιο:	58
Τεύχος:	17
Σελίδες:	2335-2346
Θεματική Κατηγορία:	[EL] Φασματοσκοπία[EN] Spectroscopy [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Χημική τεχνολογία[EN] Chemical technolgy
Λέξεις-Κλειδιά:	Block copolymers Deoxyribonucleic acid (DNA) Light scattering pH responsive Polyplexes Thermoresponsive
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Wiley Periodicals, LLC.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://onlinelibrary.wiley.com/doi/10.1002/pol.20200375
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://onlinelibrary.wiley.com/journal/26424169
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο