Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study
Δημιουργός/Συγγραφέας:	Bacalini, Maria Giulia Reale, Anna Malavolta, Marco Ciccarone, Fabio Moreno-Villanueva, María Dollé, Martijn E T Jansen, Eugène Grune, Tilman [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Schön, Christiane Bernhardt, Jürgen Grubeck-Loebenstein, Beatrix Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Capri, Miriam Hervonen, Antti Hurme, Mikko Slagboom, P Eline Breusing, Nicolle Aversano, Valentina Tagliatesta, Stefano Franceschi, Claudio Blasco, Maria A Bürkle, Alexander Caiafa, Paola Zampieri, Michele
Εκδότης:	Elsevier
Ημερομηνία:	2021-06
Γλώσσα:	Αγγλικά
ISSN:	2509-2715 2509-2723
DOI:	10.1007/s11357-021-00347-9
Άλλο:	33870444
Περίληψη:	Ageing leaves characteristic traces in the DNA methylation make-up of the genome. However, the importance of DNA methylation in ageing remains unclear. The study of subtelomeric regions could give promising insights into this issue. Previously reported associations between susceptibility to age-related diseases and epigenetic instability at subtelomeres suggest that the DNA methylation profile of subtelomeres undergoes remodelling during ageing. In the present work, this hypothesis has been tested in the context of the European large-scale project MARK-AGE. In this cross-sectional study, we profiled the DNA methylation of chromosomes 5 and 21 subtelomeres, in more than 2000 age-stratified women and men recruited in eight European countries. The study included individuals from the general population as well as the offspring of nonagenarians and Down syndrome subjects, who served as putative models of delayed and accelerated ageing, respectively. Significant linear changes of subtelomeric DNA methylation with increasing age were detected in the general population, indicating that subtelomeric DNA methylation changes are typical signs of ageing. Data also show that, compared to the general population, the dynamics of age-related DNA methylation changes are attenuated in the offspring of centenarian, while they accelerate in Down syndrome individuals. This result suggests that subtelomeric DNA methylation changes reflect the rate of ageing progression. We next attempted to trace the age-related changes of subtelomeric methylation back to the influence of diverse variables associated with methylation variations in the population, including demographics, dietary/health habits and clinical parameters. Results indicate that the effects of age on subtelomeric DNA methylation are mostly independent of all other variables evaluated.
Τίτλος πηγής δημοσίευσης:	GeroScience
Τόμος/Κεφάλαιο:	43
Τεύχος:	3
Σελίδες:	1283–1302
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry [EL] Ιατρική[EN] Medicine [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Ageing Centenarian offspring DNA methylation Down syndrome Epigenetics Subtelomere Aged, 80 and over Blood Cells Cross-Sectional Studies Europe Female Humans Male Aging DNA Methylation
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 The Authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://link.springer.com/article/10.1007/s11357-021-00347-9#rightslink
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.springer.com/journal/11357
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο