Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Microbiome in blood samples from the general population recruited in the MARK-AGE project: A pilot study
Δημιουργός/Συγγραφέας:	D'Aquila, Patrizia Giacconi, Robertina Malavolta, Marco Piacenza, Francesco Bürkle, Alexander Villanueva, María Moreno Dollé, Martijn E T Jansen, Eugène Grune, Tilman [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Grubeck-Loebenstein, Beatrix Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Hervonen, Antti Hurme, Mikko Slagboom, P Eline Schön, Christiane Bernhardt, Jürgen Breusing, Nicolle Passarino, Giuseppe Provinciali, Mauro Bellizzi, Dina
Εκδότης:	Frontiers Media
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISSN:	1664-302X
DOI:	10.3389/fmicb.2021.707515
Άλλο:	34381434
Περίληψη:	The presence of circulating microbiome in blood has been reported in both physiological and pathological conditions, although its origins, identities and function remain to be elucidated. This study aimed to investigate the presence of blood microbiome by quantitative real-time PCRs targeting the 16S rRNA gene. To our knowledge, this is the first study in which the circulating microbiome has been analyzed in such a large sample of individuals since the study was carried out on 1285 Randomly recruited Age-Stratified Individuals from the General population (RASIG). The samples came from several different European countries recruited within the EU Project MARK-AGE in which a series of clinical biochemical parameters were determined. The results obtained reveal an association between microbial DNA copy number and geographic origin. By contrast, no gender and age-related difference emerged, thus demonstrating the role of the environment in influencing the above levels independent of age and gender at least until the age of 75. In addition, a significant positive association was found with Free Fatty Acids (FFA) levels, leukocyte count, insulin, and glucose levels. Since these factors play an essential role in both health and disease conditions, their association with the extent of the blood microbiome leads us to consider the blood microbiome as a potential biomarker of human health.
Τίτλος πηγής δημοσίευσης:	Frontiers in microbiology
Τόμος/Κεφάλαιο:	12
Σελίδες:	707515
Θεματική Κατηγορία:	[EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Βιοχημεία[EN] Biochemistry [EL] Μικροβιολογία[EN] Microbiology [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	16S rRNA gene Aging Blood microbiome Free fatty acids Geographic origin Glucose Insulin Leukocytes
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.frontiersin.org/articles/10.3389/fmicb.2021.707515/full
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.frontiersin.org/journals/microbiology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο