Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Association between fat-soluble vitamins and self-reported health status: A cross-sectional analysis of the MARK-AGE cohort
Δημιουργός/Συγγραφέας:	Stokes, Caroline Sarah Weber, Daniela Wagenpfeil, Stefan Stuetz, Wolfgang Moreno-Villanueva, María Dollé, Martijn E T Jansen, Eugène [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Bernhardt, Jürgen Grubeck-Loebenstein, Beatrix Fiegl, Simone Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Capri, Miriam Hervonen, Antti Slagboom, P Eline Breusing, Nicolle Frank, Jan Bürkle, Alexander Franceschi, Claudio Grune, Tilman
Εκδότης:	Cambridge University Press on behalf of The Nutrition Society
Ημερομηνία:	2022-08-14
Γλώσσα:	Αγγλικά
ISSN:	0007-1145 1475-2662
DOI:	10.1017/S0007114521004633
Άλλο:	34794520
Περίληψη:	Self-rated health (SRH) is associated with higher risk of death. Since low plasma levels of fat-soluble vitamins are related to mortality, we aimed to assess whether plasma concentrations of vitamins A, D and E were associated with SRH in the MARK-AGE study. We included 3158 participants (52 % female) aged between 35 and 75 years. Cross-sectional data were collected via questionnaires. An enzyme immunoassay quantified 25-hydroxyvitamin D and HPLC determined α-tocopherol and retinol plasma concentrations. The median 25-hydroxyvitamin D and retinol concentrations differed significantly (P < 0·001) between SRH categories and were lower in the combined fair/poor category v. the excellent, very good and good categories (25-hydroxvitamin D: 40·8 v. 51·9, 49·3, 46·7 nmol/l, respectively; retinol: 1·67 v. 1·75, 1·74, 1·70 µmol/l, respectively). Both vitamin D and retinol status were independently associated with fair/poor SRH in multiple regression analyses: adjusted OR (95 % CI) for the vitamin D insufficiency, deficiency and severe deficiency categories were 1·33 (1·06-1·68), 1·50 (1·17-1·93) and 1·83 (1·34-2·50), respectively; P = 0·015, P = 0·001 and P < 0·001, and for the second/third/fourth retinol quartiles: 1·44 (1·18-1·75), 1·57 (1·28-1·93) and 1·49 (1·20-1·84); all P < 0·001. No significant associations were reported for α-tocopherol quartiles. Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of these modifiable nutrients on health status are warranted.
Τίτλος πηγής δημοσίευσης:	The British journal of nutrition
Τόμος/Κεφάλαιο:	128
Τεύχος:	3
Σελίδες:	433 - 443
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Στατιστική[EN] Statistics [EL] Παθολογία[EN] Pathology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Micronutrients Plasma Retinol Vitamin D α-tocopherol Humans Female Adult Middle Aged Aged Male Cross-Sectional Studies Self Report Vitamins Calcifediol Health Status Vitamin A alpha-Tocopherol
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 The Authors. Published by Cambridge University Press on behalf of The Nutrition Society
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/association-between-fatsoluble-vitamins-and-selfreported-health-status-a-crosssectional-analysis-of-the-markage-cohort/96C25EF2693A93EF7DAFE37C2B8E6307
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.cambridge.org/core/journals/british-journal-of-nutrition
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο