Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34
Δημιουργός/Συγγραφέας:	Naziris, Nikolaos Pippa, Natassa Sereti, Evangelia Chrysostomou, Varvara Kędzierska, Marta Kajdanek, Jakub Ionov, Maksim Miłowska, Katarzyna Balcerzak, Łucja Garofalo, Stefano Limatola, Cristina [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Dimas, Konstantinos Bryszewska, Maria Demetzos, Costas
Εκδότης:	MDPI
Ημερομηνία:	2021-06-10
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms22126271
Άλλο:	34200955
Περίληψη:	Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells.
Τίτλος πηγής δημοσίευσης:	International Journal of Molecular Sciences
Τόμος/Κεφάλαιο:	22
Τεύχος:	12
Σελίδες:	6271
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Βιοχημεία[EN] Biochemistry [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Chimeric liposomes Functional pH-responsive TRAM-34 Drug delivery Glioblastoma Apoptosis Cell Proliferation Drug Carriers Glioma Humans Hydrogen-Ion Concentration Liposomes Nanoparticles Polymers Pyrazoles Tumor Cells, Cultured Drug Delivery Systems
EU Grant:	HFRI PhD Fellowship International scholarship exchange of PhD Candidates and Academic Staff Era-Net EURONANOMED II European Research project “NANOGLIO”
EU Grant identifier:	GA. no. 392
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 by the authors. Licensee MDPI, Basel, Switzerland
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.mdpi.com/1422-0067/22/12/6271
Σημειώσεις:	This research was funded by the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Technology (GSRT), under the HFRI PhD Fellowship grant to N.N. (GA. no. 392) and by the Polish National Agency for Academic Exchange (NAWA PROM), under the Project Named “International scholarship exchange of PhD Candidates and Academic Staff”. The work was also funded by the GSRT (N.P., E.S., V.C., S.P., K.D., C.D.) and the Italian Ministry of Health (S.G., C.L.), under the framework of the Era-Net EURONANOMED II European Research project “NANOGLIO”.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο