Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome
Δημιουργός/Συγγραφέας:	Fotakis, Charalambos Moros, Georgios Kontogeorgou, Anna Iacovidou, Nicoletta Boutsikou, Theodora [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis
Ημερομηνία:	2022-04-12
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms23084248
Άλλο:	35457066
Περίληψη:	Normal levels of thyroid hormones (THs) are essential for a normal pregnancy outcome, fetal growth and the normal function of the central nervous system. Hypothyroidism, a common endocrine disorder during pregnancy, is a significant metabolic factor leading to cognitive impairments. It is essential to investigate whether patients with thyroid dysfunction may present an altered circulative and excreted metabolic profile, even after receiving treatment with thyroxine supplements. NMR metabolomics was employed to analyze 90 serum and corresponding colostrum samples. Parallel analyses of the two biological specimens provided a snapshot of the maternal metabolism through the excretive and circulating characteristics of mothers. The metabolomics data were analyzed by performing multivariate statistical, biomarker and pathway analyses. Our results highlight the impact of hypothyroidism on metabolites' composition during pregnancy and lactation. Thyroid disorder causing metabolite fluctuations may lead to impaired lipid and glucose metabolic pathways as well as aberrant prenatal neurodevelopment, thus posing a background for the occurrence of metabolic syndrome or neurogenerative diseases later in life. This risk applies to not only untreated but also hypothyroid women under replacement therapy since our findings in both biofluids framed a different metabolic phenotype for the latter group, thus emphasizing the need to monitor women adequately after treatment initiation.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	23
Τεύχος:	8
Θεματική Κατηγορία:	[EL] Μαιευτική και γυναικολογία[EN] Gynecology and obstetrics [EL] Λειτουργικές και συστηματικές διαταραχές. Ενδοκρινική γυναικολογία[EN] Functional and systemic disorders. Endocrine gynecology [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Thyroid disorder Thyroid hormones Metabolic pathways Early Diagnosis Fetal growth and development NMR metabolomics Chemometrics
EU Grant:	Metabolic fingerprint of mothers with hypothyroidism at lactation stage
EU Grant identifier:	MIS 5049508
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1422-0067/23/8/4248
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο