Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets
Δημιουργός/Συγγραφέας:	Karagiannakos, Alexandros Adamaki, Maria Tsintarakis, Antonis Vojtesek, Borek Fåhraeus, Robin [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Karakostis, Konstantinos
Εκδότης:	MDPI
Ημερομηνία:	2022-01-28
Γλώσσα:	Αγγλικά
ISSN:	2072-6694
DOI:	10.3390/cancers14030664
Άλλο:	35158934
Περίληψη:	Cancer is the second leading cause of death globally. One of the main hallmarks in cancer is the functional deregulation of crucial molecular pathways via driver genetic events that lead to abnormal gene expression, giving cells a selective growth advantage. Driver events are defined as mutations, fusions and copy number alterations that are causally implicated in oncogenesis. Molecular analysis on tissues that have originated from a wide range of anatomical areas has shown that mutations in different members of several pathways are implicated in different cancer types. In recent decades, significant efforts have been made to incorporate this knowledge into daily medical practice, providing substantial insight towards clinical diagnosis and personalized therapies. However, since there is still a strong need for more effective drug development, a deep understanding of the involved signaling mechanisms and the interconnections between these pathways is highly anticipated. Here, we perform a systemic analysis on cancer patients included in the Pan-Cancer Atlas project, with the aim to select the ten most highly mutated signaling pathways (p53, RTK-RAS, lipids metabolism, PI-3-Kinase/Akt, ubiquitination, b-catenin/Wnt, Notch, cell cycle, homology directed repair (HDR) and splicing) and to provide a detailed description of each pathway, along with the corresponding therapeutic applications currently being developed or applied. The ultimate scope is to review the current knowledge on highly mutated pathways and to address the attractive perspectives arising from ongoing experimental studies for the clinical implementation of personalized medicine.
Τίτλος πηγής δημοσίευσης:	Cancers
Τόμος/Κεφάλαιο:	14
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Βιοχημεία[EN] Biochemistry [EL] Βιοπληροφορική[EN] Bioinformatics
Λέξεις-Κλειδιά:	NGS Cancer patients Clinical implementation Molecular oncology Precision medicine Tumor Mutations
EU Grant:	BIOKARETRA—Identification of genomic and transcriptomic prognostic bio-signatures in head and neck cancer ENOCH MH CZ—DRO
EU Grant identifier:	Τ2EDK-03266 CZ.02.1.01/0.0/0.0/16_019/0000868 MMCI, 00209805
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2072-6694/14/3/664
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο