Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
Δημιουργός/Συγγραφέας:	Kochlik, Bastian Herpich, Catrin Moreno-Villanueva, María Klaus, Susanne Müller-Werdan, Ursula Weinberger, Birgit Fiegl, Simone Toussaint, Olivier Debacq-Chainiaux, Florence Schön, Christiane Bernhard, Jürgen Breusing, Nicolle [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Sikora, Ewa Hervonen, Antti Hurme, Mikko Slagboom, P Eline Dollé, Martijn E T Jansen, Eugene Grune, Tilman Bürkle, Alexander Norman, Kristina
Ημερομηνία:	2024-04
Γλώσσα:	Αγγλικά
ISSN:	2509-2723
DOI:	10.1007/s11357-023-00902-6
Άλλο:	37715843
Περίληψη:	Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE ("European study to establish bioMARKers of human AGEing") participants (N = 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 - 0.310], p = 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 - 4.372], p = 0.007; and adjusted odds ratio = 1.414 [1.025 - 1.951], p = 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.
Τίτλος πηγής δημοσίευσης:	GeroScience
Τόμος/Κεφάλαιο:	46
Τεύχος:	2
Θεματική Κατηγορία:	[EL] Γηριατρική[EN] Geriatrics [EL] Βιοχημεία[EN] Biochemistry [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology
Λέξεις-Κλειδιά:	Aging Biomarker Cognitive frailty Depression GDF15
EU Grant:	European Study to Establish Biomarkers of Human Ageing f4f— food for the future
EU Grant identifier:	200880 491394008 031B0731E
Κάτοχος πνευματικών δικαιωμάτων:	© 2023. The Author(s)
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi. org/10.1007/s11357-023-00902-6
Σημειώσεις:	Open Access funding enabled and organized by Projekt DEAL. We thank the European Commission for financial support through the FP7 large-scale integrating project ‘European Study to Establish Biomarkers of Human Ageing’ (MARK-AGE; grant agreement no. 200880). We also would like to thank the Focus Area DynAge for financially supporting GDF15 analyses as well as the German Federal Ministry of Education and Research (grant agreement no. 031B0731E) as part of the joint project “f4f— food for the future” in the BMBF initiative “Agricultural systems of the future” for partially supporting this work. Moreover, publication costs were funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491394008. The online version contains supplementary material available at https://doi.org/10.1007/s11357-023-00902-6.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο