|
ΉΛΙΟΣ - Αποθετήριο ΕΙΕ >
National Hellenic Research Foundation >
Institute of Biological Research and Biotechnology (IBRB) >
Institute of Biological Research and Biotechnology (IBRB) Collection >
| Title | The role of ATF-2 in oncogenesis |
| Creator | |
| Date | 17 March 2008 |
| Language | English |
| Type | Article |
| Alternative Location | http://dx.doi.org/10.1002/bies.20734
| | Source | BioEssays 30:4(Mar2008):314-327 |
| Description | Journal Web Location: Journal URL:http://www3.interscience.wiley.com/journal/34201/home |
| Subject Category (LCC) | Neoplasms. Tumors. Oncology |
| Abstract | Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize the signaling pathways that activate ATF-2, as well as its downstream targets. We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design. |
The full text of this item is currently not available in Helios |
All items in Helios are protected by copyright.
|
