Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence: Platelet aggregation and relaxant activities

Alexopoulos, K.; Fatseas, P.; Melissari, E.; Vlahakos, D.; Roumelioti, P.; Mavromoustakos, Thomas; Mihailescu, S.; Paredes-Carbajal, M. C.; Mascher, D.; Matsoukas, J.

doi:DOI: http://dx.doi.org/10.1021/jm031080v

K. Alexopoulos, P. Fatseas, E. Melissari, D. Vlahakos, P. Roumelioti, T. Mavromoustakos, S. Mihailescu, M. C. Paredes-Carbajal, D. Mascher, and J. Matsoukas, “Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence: Platelet aggregation and relaxant activities,” Journal of Medicinal Chemistry, vol. 47, no. 13, pp. 3338-3352, 2004.

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Title:	Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence: Platelet aggregation and relaxant activities
Author/Creator:	Alexopoulos, K. Fatseas, P. Melissari, E. Vlahakos, D. Roumelioti, P. Mavromoustakos, Thomas Mihailescu, S. Paredes-Carbajal, M. C. Mascher, D. Matsoukas, J.
Date:	2004
Type:	Journal Article (Scientific Journal article)
Publisher:	American Chemical Society
Journal Title:	Journal of Medicinal Chemistry
Volume:	47
Issue:	13
Pages:	3338-3352
Peer Reviewed:	Yes
Language:	English
ISSN:	0022-2623
URL:	http://hdl.handle.net/10442/8019
Other Identifiers:	DOI: http://dx.doi.org/10.1021/jm031080v
Journal web Location :	http://pubs.acs.org/journals/jmcmar/index.html
Source:	Journal of Medicinal Chemistry 47:13(Jun2004):3338-3352