Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Peptidomimetic–functionalized carbon nanotubes with antitrypsin activity
Δημιουργός/Συγγραφέας:	Karousis, Nikolaos Papi, Rigini M. Siskos, Argiris Vakalopoulou, Paraskevi Glezakos, Petros Sarigiannis, Yiannis Stavropoulos, Georgios [EL] Κυριακίδης, Δ.Α.[EN] Kyriakidis, D.A. [EL] Ταγματάρχης, Νίκος[EN] Tagmatarchis, Nikos
Εκδότης:	Elsevier Ltd.
Ημερομηνία:	2009-12
Γλώσσα:	Αγγλικά
ISSN:	0008-6223
DOI:	10.1016/j.carbon.2009.08.025
Περίληψη:	Water-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics. The structural design of the covalently grafted peptidomimetics to the CNTs is based on their structural similarity with the metabolites of antagonist G of substance P. A variety of analytical spectroscopic methods, in combination with electron microscopy and thermal analysis, aided the structural and morphological characterization of the four newly synthesized peptidomimetic–CNT conjugates. It is demonstrated that the trypsin inhibitory effect of the peptidomimetic–CNT is enhanced as a result of the high-loading of peptidomimetics onto the skeleton of the modified water-soluble CNTs. Additionally, the peptidomimetic– functionalized CNT conjugates can be recovered and re-employed up to six biological evaluation cycles showing the same trypsin inhibitory activity. Such a nanosized system is extremely advantageous for the inhibition of inflammation or malignancy and could find potential future biological applications in the area of drug delivery systems.
Τίτλος πηγής δημοσίευσης:	CARBON
Τόμος/Κεφάλαιο:	47
Σελίδες:	3550-3558
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Βιολογία (Γενικά)[EN] Biology (General)
Κάτοχος πνευματικών δικαιωμάτων:	© 2009 Elsevier Ltd. All rights reserved
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.elsevier.com/locate/carbon
Εμφανίζεται στις συλλογές:	Άλλα