@article{Koufaki_Theodorou_Alexi_Nikoloudaki_Alexis_2010, title={Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity}, volume={45}, ISSN={0223-5234}, archiveLocation={Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο}, url={https://hdl.handle.net/10442/12280}, DOI={10.1016/j.ejmech.2009.12.006}, abstractNote={beta-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues were found to exhibit anticancer and anti-ischemic activity. However, the ability of tropolone derivatives to protect neuronal cells from oxidative stress-induced cell damage has not been studied so far. As an ongoing effort toward highly effective antioxidants with potential neuroprotective activity, we have synthesized 7-substituted derivatives of beta-thujaplicin and its methoxy analogue. The substituents were heterocycles (piperazine, morpholine) or heteroaromatics (triazoles, pyridine). Only the piperazine derivatives of beta-thujaplicin were able to protect HT22 hippocampal neurons from oxidative stress-induced cell death.}, number={3}, journal={European Journal of Medicinal Chemistry}, publisher={Elsevier France, Editions Scientifiques et Medicales}, author={Koufaki, Maria and Theodorou, Elissavet and Alexi, Xanthippi and Nikoloudaki, Faidra and Alexis, Michael N.}, year={2010}, month={Mar}, pages={1107–1112} }