%0 Journal Article %A Skaltsas T.%A %A Goulielmaki M.%A %A Pintzas A.%A %A Pispas S.%A %A Tagmatarchis N. %D 2017 %T Carbon quantum dots/block copolymer ensembles for metal-ion sensing and bioimaging %J Journal of Materials Chemistry B %V 5 %@ 2050-7518 %R 10.1039/c7tb01352c %I Royal Society of Chemistry %P 5397–5402 %N 27 %U https://hdl.handle.net/10442/16955 %X Fluorescent carbon quantum dots (CQDs) rich in amine moieties that can be easily protonated under acidic conditions were electrostatically interacted with diblock copolymer poly[sodium(carboxylate sulfamate) isoprene]-b-poly(ethylene oxide) (CSS-IEO-3) possessing negatively charged sulfamate and carboxylate species on the CSS part of the diblock copolymer. The so-formed CQDs/CSS-IEO-3 material was found to be stable in a neutral and high salinity environment, which is critical when aiming for biological applications. Moreover, the photoluminescence of CQDs within CQDs/CSS-IEO-3, with emission at 420 nm upon excitation at 320 nm, was unaffected by pH and salinity changes, denoting the absence of significant aggregation phenomena and highlighting the potential of CQDs/CSS-IEO-3 for bioimaging. The photoluminescence of CQDs/CSS-IEO-3 was employed to develop a selective and sensitive method for the facile detection of Fe3+, in the presence of other metal salts, with a detection limit of 8.37 μM. Furthermore, integration of bovine serum albumin (BSA) furnished the three-component CQDs/CSS-IEO-3·BSA nanoensemble, without causing cytotoxicity when subjected to RKO human colon adenocarcinoma cell line. Evidently, confocal fluorescence microscopy allowed the imaging of CQDs/CSS-IEO-3·BSA within living cells, and illustrated its application potential for bioimaging and drug delivery. %> Αποθετήριο Ήλιος / ΕΙΕ