%0 Journal Article %A Galtsidis S.%A %A Logotheti S.%A %A Pavlopoulou A.%A %A Zampetidis C.P.%A %A Papachristopoulou G.%A %A Scorilas A.%A %A Vojtesek B.%A %A Gorgoulis V.%A %A Zoumpourlis V. %D 2017 %T Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness %J Cancer Letters %V 388 %@ 0304-3835 %R 10.1016/j.canlet.2016.11.036 %I Elsevier Ireland Ltd %P 96–106 %U https://hdl.handle.net/10442/17420 %X The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated networks which are commonly perturbed in cancer. Herein, we aimed to characterize a p73-regulated network that mediates cell migration and restores anti-oncogenic responses in p53-mutant cancer cells. In this study, we demonstrate that p73 regulates a network underlying cell migration, which consists of MIR34A/MIR3158/vimentin/β-catenin/lef1. The p73 isoforms transactivate the miRNA components (MIR34A/MIR3158) of this network, which in turn, downregulate their EMT-related mRNA co-targets (vimentin/β-catenin/lef1) to decrease cell-migration. Modulation of this network, by increasing the level of the novel p73-dependent target MIR3158, was found to induce anti-oncogenic/anti-invasive responses in p53-mutant cancer cells. Taken together, a p73-regulated, MIR3158-containing, network restores anti-invasive phenotypes in p53-mutant cancer cells; this property could be exploited towards the development of anticancer therapeutics. %> Αποθετήριο Ήλιος / ΕΙΕ