%0 Journal Article %A Ramaswamy S.%A %A Sleiman M.H.%A %A Masuyer G.%A %A Arbez-Gindre C.%A %A Micha-Screttas M.%A %A Calogeropoulou T.%A %A Steele B.R.%A %A Acharya, K. R. %D 2015 %T Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7 %J FEBS Journal %V 282 %@ 1742-464X %R 10.1111/febs.13140 %I Blackwell Publishing Ltd %P 372–387 %N 2 %U https://hdl.handle.net/10442/17548 %X Galectins are evolutionarily conserved and ubiquitously present animal lectins with a high affinity for β-galactose-containing oligosaccharides. To date, 15 mammalian galectins have been identified. Their involvement in cell-cell and cell-matrix interactions has highlighted their importance in signal transduction and other intracellular processes. Human galectin-7 (hGal-7) is a 15 kDa proto type galectin that forms a dimer in solution and its involvement in the stimulation and development of tumour growth has been reported. Previously, we reported the crystal structure of hGal-7 and its complex with galactose and lactose which provided insight into its molecular recognition and detailed interactions. Here, we present newly obtained high-resolution structural data on carbohydrate-based dendrons in complex with hGal-7. Our crystallographic data reveal how multivalent ligands interact with and form cross-links with these galectin molecules. Understanding how these dendrimeric compounds interact with hGal-7 would help in the design of new tools to investigate the recognition of carbohydrates by lectins. %> Αποθετήριο Ήλιος / ΕΙΕ