%0 Journal Article %A %A Castagné, Raphaële%A %A Kelly-Irving, Michelle%A %A Krogh, Vittorio%A %A Palli, Domenico%A %A Panico, Salvatore%A %A Sacerdote, Carlotta%A %A Tumino, Rosario%A %A Hebels, Dennie Gaj%A %A Kleinjans, Jos Cs%A %A de Kok, Theo McM%A et al. %D 2020 %T A multi-omics approach to investigate the inflammatory response to life course socioeconomic position %J Epigenomics %V 12 %@ 1750-1911 %R 10.2217/epi-2019-0261 %P 1287–1302 %N 15 %U https://hdl.handle.net/10442/17834 %X Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation. %> Αποθετήριο Ήλιος / ΕΙΕ