TY - JOUR ID - 10442/12276 A1 - Tchokouaha, R. F. A1 - A1 - Alexi, X. A1 - A1 - Chosson, E. A1 - A1 - Besson, T. A1 - A1 - Skaltsounis, A.-L. A1 - A1 - Seguin, E. A1 - A1 - Alexis, M. N. A1 - A1 - Wandji, J. Y1 - 2010/// T1 - Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells JF - Journal of Enzyme Inhibition and Medicinal Chemistry VL - 25 IS - 2 SN - 1475-6366 U3 - 10.3109/14756360903169972 PB - Taylor & Francis Limited SP - 228–233EP - UR - https://hdl.handle.net/10442/12276 N2 - Two new dimethylpyrano-isoflavones, named erymildbraedin A (4) and B (5), were isolated from the stem bark of the Cameroonian medicinal plant Erythrina mildbraedii, along with four known ones, the linear congeners, scandenone (1), erysenegalinsein M (2), 5,4’-dihydroxy-2’-methoxy-8-(3,3-dimethylallyl)-2 ’,2 ’-dimethylpyrano[5,6:6,7]isoflavone (3), and the angular isoflavone eryvarin B (6), and two other compounds, fraxidin and scoparone. Their structures were elucidated by the usual spectroscopic methods and isoflavone effects on the growth of human breast, prostate, and endometrial adenocarcinoma cells were determined. Isoflavones 1, 3, and 6 strongly inhibited the growth of all three cell lines, supporting the notion that a non-oxidized isoprenyl group at C-8 is requisite for cytotoxic activity. ER -