TY - JOUR ID - 10442/12310 A1 - Daskalos, A. A1 - A1 - Logotheti, S. A1 - A1 - Markopoulou, S. A1 - A1 - Xinarianos, G. A1 - A1 - Gosney, J. R. A1 - A1 - Kastania, A. N. A1 - A1 - Zoumpourlis, V. A1 - A1 - Field, J. K. A1 - A1 - Liloglou, T. Y1 - 2011/// T1 - Global DNA hypomethylation-induced Delta Np73 transcriptional activation in non-small cell lung cancer JF - Cancer Letters VL - 300 IS - 1 SN - 0304-3835 U3 - 10.1016/j.canlet.2010.09.009 PB - Elsevier Ireland Limited SP - 79–86EP - UR - https://hdl.handle.net/10442/12310 N2 - p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the anti-apoptotic Delta Np73 isoforms respectively In this study we investigated the DNA methylation status of both promoters as a means of epigenetic transcriptional control of their corresponding isoforms in 102 primary non-small cell lung carcinomas (NSCLCs) We demonstrated that while P1 hypermethylation-associated reduction of TAp73 mRNA levels is relatively infrequent the P2 hypomethylation-associated over-expression of Delta Np73 mRNA is a frequent event particularly among squamous cell carcinomas P2 hypomethylation strongly correlated with LINE-1 element hypomethylation indicating that Delta Np73 over-expression may be a passive consequence of global DNA hypomethylation ER -