TY - JOUR ID - 10442/17834 A1 - A1 - Castagné, R. A1 - A1 - Kelly-Irving, M. A1 - A1 - Krogh, V. A1 - A1 - Palli, D. A1 - A1 - Panico, S. A1 - A1 - Sacerdote, C. A1 - A1 - Tumino, R. A1 - A1 - Hebels, D. G. A1 - A1 - Kleinjans, J. C. A1 - A1 - de Kok, T. M. A1 - et al. Y1 - 2020/// T1 - A multi-omics approach to investigate the inflammatory response to life course socioeconomic position JF - Epigenomics VL - 12 IS - 15 SN - 1750-1911 U3 - 10.2217/epi-2019-0261 SP - 1287–1302EP - UR - https://hdl.handle.net/10442/17834 N2 - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation. ER -