Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Overexpression of hnRNPA2/B1 in Bronchoscopic Specimens: A Potential Early Detection Marker in Lung Cancer
Δημιουργός/Συγγραφέας:	Katsimpoula, S. [EL] Πατρινού-Γεωργούλα, Μερόπη[EN] Patrinou-Georgoula, Meropi Makrilia, N. Dimakou, K. [EL] Γκιάλη, Αποστολία[EN] Guialis, Apostolia Orfanidou, D. Syrigos, K. N.
Εκδότης:	International Institute of Anticancer Research
Τόπος έκδοσης:	ATHENS
Ημερομηνία:	2009-04
Γλώσσα:	Αγγλικά
ISSN:	0250-7005
Περίληψη:	Background: Overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has recently been suggested to be a promising marker for early detection of lung cancer. The aim of this study was to determine the utility of its detection in bronchoscopic specimens. Patients and Methods: Brushing and biopsy specimens were obtained from 61 patients suspected of having lung cancer, as well as from 30 healthy subjects (controls), who underwent bronchoscopy. hnRNPA2/B1 expression levels were evaluated by immunoblotting. Results: Specificity of hnRNP A2/B1 overexpression was 75.9% in brushing and 78.3% in biopsy. Sensitivity in non-small cell lung cancer was 84.8% in brushing and 80.8% in biopsies, while in small cell lung cancer it was 66.7% and 75%, respectively. Overexpression of hnRNPA2/B1 was also detected in bronchoscopic specimens of nine patients initially undiagnosed. The follow-up of these patients 2 years later showed that seven of them had developed lung cancer. Conclusion: Overexpression of hnRNPA2/B1 was significantly higher in patients suffering from lung cancer and may be useful in the early detection of lung cancer.
Τίτλος πηγής δημοσίευσης:	Anticancer Research
Τόμος/Κεφάλαιο:	29
Τεύχος:	4
Σελίδες:	1373-1382
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)
Λέξεις-Κλειδιά:	Biomarker brushing hnRNPA2/B1 immunoblotting lung cancer
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© INT INST ANTICANCER RESEARCH
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο