Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: Findings from two prospective cohorts
Δημιουργός/Συγγραφέας:	Berger E. Delpierre C. Hosnijeh F.S. Kelly-Irving M. Portengen L. Bergdahl I.A. Johansson A.-S. Krogh V. Palli D. Panico S. Sacerdote C. Tumino R. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Vineis P. Chadeau-Hyam M. Vermeulen R. Castagné R. Melin B. Lenner P. Bendinelli B. Botsivali M. [EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis Valavanis I. Bodinier B. Garrido-Manriquez J. Athersuch T.J. Liquet B. Lokhorst H. [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis Kleinjans J.C.S. De Kok T.M.C.M. Keun H.C. Kelly R. Hallmans G. Stephanou E.G. Myridakis A. Kogevinas M. Fazzo L. De Santis M. Comba P. Kiviranta H. Rantakokko P. Airaksinen R. Ruokojarvi P. Gilthorpe M. Fleming S. Fleming T. Tu Y.-K. Lundh T. Chien K.-L. Chen W.J. Lee W.-C. Hsiao C.K. Kuo P.-H. Hung H. Liao S.-F.
Εκδότης:	Nature Publishing Group
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	2045-2322
DOI:	10.1038/s41598-018-29041-1
Άλλο:	PubMed ID: 30018397
Περίληψη:	Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.
Τίτλος πηγής δημοσίευσης:	Scientific Reports
Τόμος/Κεφάλαιο:	8
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 The Author(s).
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	Horizon 2020 Framework Programme, H2020: 633666; Seventh Framework Programme, FP7: 226756; European Commission, EC; Ligue Contre le Cancer; Institut National Du Cancer, INCa: SHSESP14-082. This work has been carried out as part of the 7th European Framework Programme (FP7) Envirogenomarkers [226756 to S.K.] project. This work was supported by the Institut National du Cancer [SHSESP14-082 to R.C.]. This work was funded by the European Commission as part of the Lifepath project [H2020 grant number 633666]. This work was supported by La Ligue nationale contre le cancer [Equipe Labellisée LIGUE 2017/CD]).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο