Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
Δημιουργός/Συγγραφέας:	Berdiel-Acer, Mireia Maia, Ana Hristova, Zhivka Borgoni, Simone Vetter, Martina Burmester, Sara Becki, Corinna Michels, Birgitta Abnaof, Khalid Binenbaum, Ilona Bethmann, Daniel [EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis Hasmann, Max Thomssen, Christoph Espinet, Elisa Wiemann, Stefan
Εκδότης:	Springer Nature
Ημερομηνία:	2021-04
Γλώσσα:	Αγγλικά
ISSN:	0950-9232 1476-5594
DOI:	10.1038/s41388-021-01719-3
Άλλο:	33692466
Περίληψη:	HER3 is highly expressed in luminal breast cancer subtypes. Its activation by NRG1 promotes activation of AKT and ERK1/2, contributing to tumour progression and therapy resistance. HER3-targeting agents that block this activation, are currently under phase 1/2 clinical studies, and although they have shown favorable tolerability, their activity as a single agent has proven to be limited. Here we show that phosphorylation and activation of HER3 in luminal breast cancer cells occurs in a paracrine manner and is mediated by NRG1 expressed by cancer-associated fibroblasts (CAFs). Moreover, we uncover a HER3-independent NRG1 signaling in CAFs that results in the induction of a strong migratory and pro-fibrotic phenotype, describing a subtype of CAFs with elevated expression of NRG1 and an associated transcriptomic profile that determines their functional properties. Finally, we identified Hyaluronan Synthase 2 (HAS2), a targetable molecule strongly correlated with NRG1, as an attractive player supporting NRG1 signaling in CAFs.
Τίτλος πηγής δημοσίευσης:	Oncogene
Τόμος/Κεφάλαιο:	40
Τεύχος:	15
Σελίδες:	2651–2666
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοπληροφορική[EN] Bioinformatics [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Breast Neoplasms Cancer-Associated Fibroblasts Female Humans Neuregulin-1 Proteomics Tumor Microenvironment
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 The Authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.nature.com/articles/s41388-021-01719-3#rightslink
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.nature.com/onc/
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο