Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Effective DNA damage response after acute but not chronic immune challenge: SARS-CoV-2 vaccine versus Systemic Lupus Erythematosus
Δημιουργός/Συγγραφέας:	Ntouros, Panagiotis A Vlachogiannis, Nikolaos I Pappa, Maria Nezos, Adrianos Mavragani, Clio P Tektonidou, Maria G [EL] Σουλιώτης, Βασίλης Λ.[EN] Souliotis, Vassilis L. Sfikakis, Petros P
Εκδότης:	Elsevier
Ημερομηνία:	2021-08
Γλώσσα:	Αγγλικά
ISSN:	15216616
DOI:	10.1016/j.clim.2021.108765
Άλλο:	34089859
Περίληψη:	Whether and how an acute immune challenge may affect DNA Damage Response (DDR) is unknown. By studying vaccinations against Influenza and SARS-CoV-2 (mRNA-based) we found acute increases of type-I interferon-inducible gene expression, oxidative stress and DNA damage accumulation in blood mononuclear cells of 9 healthy controls, coupled with effective anti-SARS-CoV-2 neutralizing antibody production in all. Increased DNA damage after SARS-CoV-2 vaccine, partly due to increased oxidative stress, was transient, whereas the inherent DNA repair capacity was found intact. In contrast, in 26 patients with Systemic Lupus Erythematosus, who served as controls in the context of chronic immune activation, we validated increased DNA damage accumulation, increased type-I interferon-inducible gene expression and induction of oxidative stress, however aberrant DDR was associated with deficiencies in nucleotide excision repair pathways. These results indicate that acute immune challenge can indeed activate DDR pathways, whereas, contrary to chronic immune challenge, successful repair of DNA lesions occurs.
Τίτλος πηγής δημοσίευσης:	Clinical immunology (Orlando, Fla.)
Τόμος/Κεφάλαιο:	229
Σελίδες:	108765
Θεματική Κατηγορία:	[EL] Κυτταρολογία[EN] Cytology [EL] Ανοσολογία[EN] Immunology [EL] Βιοχημεία[EN] Biochemistry [EL] Ιατρική[EN] Medicine [EL] Μικροβιολογία[EN] Microbiology
Λέξεις-Κλειδιά:	Acute immune activation Chronic immune activation DNA damage response Influenza Oxidative stress SARS-CoV-2 Type I interferon Vaccination Adolescent Adult Aged Antibodies, Neutralizing COVID-19 COVID-19 Vaccines Case-Control Studies Female Gene Expression Regulation Humans Interferon Type I Lupus Erythematosus, Systemic Male Middle Aged Oxidative Stress SARS-CoV-2 Vaccines, Synthetic Young Adult DNA Damage
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S1521661621001029?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/clinical-immunology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο