Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia
Δημιουργός/Συγγραφέας:	Poulain, Michel Herm, Anne Errigo, Alessandra Chrysohoou, Christina Legrand, Romain Passarino, Giuseppe Stazi, Maria Antonietta [EL] Βουτετάκης, Κωνσταντίνος[EN] Voutetakis, Konstantinos [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Pes, Giovanni M
Εκδότης:	Elsevier
Ημερομηνία:	2021-09
Γλώσσα:	Αγγλικά
ISSN:	00476374
DOI:	10.1016/j.mad.2021.111543
Άλλο:	34265327
Περίληψη:	Human longevity may be found in single individuals as well as in the population as a whole ("population longevity"). Longevity Blue Zones (LBZs), which are areas with an unusually high number of oldest old, have been identified in Sardinia and the Greek island of Ikaria. We compared the lifestyle, health status and some genetic markers of the LBZ populations with those of reference populations from Italy and Greece; the data were extracted from the GEHA database. In the LBZs, the proportion of individuals who never married or were married and still living with their spouse was significantly greater. Nonagenarians males and females with a high self‒perception of optimism and/or a high score for self-rated health were also found in larger proportions in LBZs. Among the variables with lower frequency were the proportion of the widowed, the percentage of subjects who had suffered a stroke and the frequency of Apoε4 and Apoε2 and the TT genotype of FOXO3A gene. Compared to behavioral and health indicators, the impact of genetic factors might be relatively less important in the LBZs. Nevertheless, further research is needed to identify potential epigenetic traits that might play a predominant role due to the interaction between genetics and the human and physical environments.
Τίτλος πηγής δημοσίευσης:	Mechanisms of ageing and development
Τόμος/Κεφάλαιο:	198
Σελίδες:	111543
Θεματική Κατηγορία:	[EL] Γενετική[EN] Genetics [EL] Δημογραφία. Πληθυσμός. Γεγονότα ανθρώπινης ζωής[EN] Demography. Population. Vital events [EL] Κοινωνική ψυχολογία[EN] Social psychology [EL] Βιοπληροφορική[EN] Bioinformatics [EL] Βάσεις δεδομένων[EN] Databases [EL] Στατιστική[EN] Statistics
Λέξεις-Κλειδιά:	Behavioral factors Genetic markers Longevity Blue Zones Nonagenarians Population longevity Aged, 80 and over Databases, Genetic Epigenomics Female Genetic Profile Humans Longevity Male Self Concept Health Status Healthy Aging Life Style Nonagenarians Optimism
Τοπική Κάλυψη:	Greece Italy
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Published by Elsevier B.V.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.mad.2021.111543
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/mechanisms-of-ageing-and-development
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο