Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Universal Markers Unveil Metastatic Cancerous Cross-Sections at Nanoscale
Δημιουργός/Συγγραφέας:	Bakalis, Evangelos Ferraro, Angelo Gavriil, Vassilios Pepe, Francesco [EL] Κόλλια, Ζωή[EN] Kollia, Zoe [EL] Κεφαλάς, Αλκιβιάδης Κωνσταντίνος[EN] Cefalas, Alciviadis Constantinos Malapelle, Umberto [EL] Σαραντοπούλου, Ευαγγελία[EN] Sarantopoulou, Evangelia Troncone, Giancarlo Zerbetto, Francesco
Ημερομηνία:	2022-07-31
Γλώσσα:	Αγγλικά
ISSN:	2072-6694
DOI:	10.3390/cancers14153728
Άλλο:	35954392
Περίληψη:	The characterization of cancer histological sections as metastatic, M, or not-metastatic, NM, at the cellular size level is important for early diagnosis and treatment. We present timely warning markers of metastasis, not identified by existing protocols and used methods. Digitized atomic force microscopy images of human histological cross-sections of M and NM colorectal cancer cells were analyzed by multifractal detrended fluctuation analysis and the generalized moments method analysis. Findings emphasize the multifractal character of all samples and accentuate room for the differentiation of M from NM cross-sections. Two universal markers emphatically achieve this goal performing very well: (a) the ratio of the singularity parameters (left/right), which are defined relative to weak/strong fluctuations in the multifractal spectrum, is always greater than 0.8 for NM tissues; and (b) the index of multifractality, used to classify universal multifractals, points to log-normal distribution for NM and to log-Cauchy for M tissues. An immediate large-scale screening of cancerous sections is doable based on these findings.
Τίτλος πηγής δημοσίευσης:	Cancers
Τόμος/Κεφάλαιο:	14
Τεύχος:	15
Σελίδες:	3728
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology
Λέξεις-Κλειδιά:	Atomic force microscopy imaging Metastatic cancer Multifractal analysis
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2072-6694/14/15/3728
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο