Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Inducing the formation of a colloidal albumin carrier of curcumin
Δημιουργός/Συγγραφέας:	Matskou, Konstantina Kisaoglan, Berke Mavroidi, Barbara Pelecanou, Maria [EL] Ζουμπανιώτη, Μαρία[EN] Zoumpanioti, Maria Matis, Ilias [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2022
Γλώσσα:	Αγγλικά
ISSN:	2666934X
DOI:	10.1016/j.jciso.2022.100051
Περίληψη:	The administration and delivery of pharmaceuticals faces a variety of well-known obstacles that result in limited biocompatibility and bioavailability. Efforts to improve these properties have often employed serum albumin, primarily due to its inherent biocompatibility and its ability to enhance the circulation times of pharmaceuticals. In this work, we have adapted a nanoparticle-formulation protocol, to produce a protein carrier of curcumin with bovine serum albumin. This was achieved by using a near-equimolar protein:curcumin ratio instead of the abundance of curcumin that would be normally used in a nanoparticle formulation. Photometric and quantitative analysis of this carrier showed an increased curcumin content in the produced aqueous solutions following the homogenization of bovine serum albumin (water) and curcumin (dichloromethane) phases. Albumin fluorescence studies indicated curcumin association near a tryptophan residue, without excluding the possibility of additional sites. Circular dichroism provided strong evidence of this association through the induced circular dichroism effect and showed that the secondary structure of bovine serum albumin was effectively maintained. Overall, this work presented a new means of facilitating the association of increased levels of curcumin with bovine serum albumin, which could potentially be used to generate additional non-covalent albumin carriers for pharmaceutical compounds.
Τίτλος πηγής δημοσίευσης:	JCIS Open
Τόμος/Κεφάλαιο:	6
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	Bovine serum albumin Homogenization Non-covalent association Equimolar protein-binder
EU Grant:	CO2-BioProducts
EU Grant identifier:	MIS 5031682
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 The Authors. Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S2666934X22000095?via%3Dihub#abs0010
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο