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ΤύποςΗμερομηνίαΤίτλοςΔημιουργόςΠλήρες κείμενο
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2012N-(4-Substituted-benzoyl)-N '-(beta-D-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methodsVeronika Nagy; Nora Felfoeldi; Balint Konya; Praly, Jean-Pierre; Tibor Docsa; Pal Gergely; Chrysina, Evangelia D.; Tiraidis, Costas; Kosmopoulou, Magda N.; Alexacou, Kyra-Melinda; Konstantakaki, Maria; Leonidas, Demetres D.; Zographos, Spyros E.; Oikonomakos, Nikos G.; Kozmon, Stanislav; Tvaroska, Igor; Laszlo Somsak
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20123 '-Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest WhyManta, Stella; Xipnitou, Andromachi; Kiritsis, Christos; Kantsadi, Anastassia L.; Hayes, Joseph M.; Skamnaki, Vicky T.; Lamprakis, Christos; Kontou, Maria; Zoumpoulakis, Panagiotis; Zographos, Spyros E.; Leonidas, Demetres D.; Komiotis, Dimitri
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2012The s-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase bKantsadi, Anastasia L.; Hayes, Joseph M.; Manta, Stella; Skamnaki, Vicky T.; Kiritsis, Christos; Psarra, Anna-Maria G.; Koutsogiannis, Zissis; Dimopoulou, Athina; Theofanous, Stavroula; Nikoleousakos, Nikolaos; Zoumpoulakis, Panagiotis; Kontou, Maria; Papadopoulos, George; Zographos, Spyros E.; Komiotis, Dimitris; Leonidas, Demetres D.
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2008New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic AgentsSomsak, L.; Czifrak, K.; Toth, M.; Bokor, E.; Chrysina, Evangelia D.; Alexacou, K. -M.; Hayes, J. M.; Tiraidis, C.; Lazoura, E.; Leonidas, Demetres D.; Zographos, Spyros E.; Oikonomakos, Nikos G.
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2008Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studiesWen, Xiaoan; Sun, Hongbin; Liu, Jun; Cheng, Keguang; Zhang, Pu; Zhang, Liying; Hao, Jia; Zhang, Luyong; Ni, Peizhou; Zographos, Spyros E.; Leonidas, Demetres D.; Alexacou, Kyra-Melinda; Gimisis, Thanasis; Hayes, Joseph M.; Oikonomakos, Nikos G.
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2008Pentacyclic triterpenes, inhibitors of glycogen phosphorylase, as potential drugs for type 2 diabetes: X-ray crystallographic studiesZographos, Spyros E.; Leonidas, Demetres D.; Alexacou, K. M.; Gimisis, T.; Hayes, J. M.; Oikonomakos, Nikos G.; Wen, X.; Sun, H.; Liu, J.; Cheng, K.; Zhang, P.; Zhang, L.; Hao, J.; Zhang, L.; Ni, P.
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20101-(3-Deoxy-3-fluoro-beta-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studiesTsirkone, Vicky G.; Tsoukala, Evangelia; Lamprakis, Christos; Manta, Stella; Hayes, Joseph M.; Skamnaki, Vicky T.; Drakou, Christina; Zographos, Spyros E.; Komiotis, Dimitri; Leonidas, Demetres D.
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2011Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylaseAlexacou, Kyra-Melinda; Zhang, Yun Zhi; Praly, Jean-Pierre; Zographos, Spyros E.; Chrysina, Evangelia D.; Oikonomakos, Nikos G.; Leonidas, Demetres D.
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2006Indirubin and indigo analogues as potential inhibitors of glycogenolysis: structural basis of glycogen phosphorylase inhibitionOikonomakos, Nikos G.; Kosmopoulou, Magda N.; Leonidas, Demetres D.; Chrysina, Evangelia D.; Tiraidis, Costas; Bischler, Nicolas; Tsitsanou, Katerina E.; Zographos, Spyros E.; Kostas, Ioannis D.; Eisenbrand, Gerhard
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2009Morpholino, Piperidino, and Pyrrolidino Derivatives of Pyrimidine Nucleosides as Inhibitors of Ribonuclease A: Synthesis, Biochemical, and Crystallographic EvaluationSamanta, Anirban; Leonidas, Demetres D.; Dasgupta, Swagata; Pathak, Tanmaya; Zographos, Spyros E.; Oikonomakos, Nikos G.
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