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ΤύποςΗμερομηνίαΤίτλοςΔημιουργόςΠλήρες κείμενο
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1998A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activityAlexopoulos, K.; Matsoukas, J.; Tselios, T.; Roumelioti, P.; Mavromoustakos, Thomas; Holada, K.
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1998A comparative SAR study of thrombin receptor derived non peptide mimetics: Importance of phenyl/guanidino proximity for activityAlexopoulos, K.; Matsoukas, J.; Tselios, T.; Roumelioti, P.; Mavromoustakos, Thomas; Holada, K.
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1999An effort to understand the molecular basis of hypertension through the study of conformational analysis of Losartan and Sarmesin using a combination of nuclear magnetic resonance spectroscopy and theoretical calculationsMavromoustakos, Thomas; Kolocouris, A.; Zervou, Maria; Roumelioti, P.; Matsoukas, J.; Weisemann, R.
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2000The design and synthesis of a potent Angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone Angiotensin IIMatsoukas, J. M.; Polevaya, L.; Ancans, J.; Mavromoustakos, Thomas; Kolocouris, A.; Roumelioti, P.; Vlahakos, D. V.; Yamdagni, R.; Wu, Q.; Moore, G. J.
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2000Structural comparison between type I and type II antagonists: Possible implications in the drug design of AT1 antagonistsRoumelioti, P.; Tselios, T.; Alexopoulos, K.; Mavromoustakos, Thomas; Kolocouris, A.; Moore, G. J.; Matsoukas, J. M.
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2001Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi*-pi* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonistsPolevaya, L.; Mavromoustakos, Thomas; Zoumpoulakis, Panagiotis; Grdadolnik, S. G.; Roumelioti, P.; Giatas, N.; Mutule, I.; Keivish, T.; Vlahakos, D. V.; Iliodromitis, E. K.; Kremastinos, D. T.; Matsoukas, J.
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2002Design, synthesis and biological evaluation of cyclic Angiotensin II analogues with 3,5 side-chain bridges: Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonistsRoumelioti, P.; Polevaya, L.; Zoumpoulakis, Panagiotis; Giatas, N.; Mutule, I.; Keivish, T.; Zoga, A.; Vlahakos, D.; Iliodromitis, E.; Kremastinos, D.; Grdadolnik, S. G.; Mavromoustakos, Thomas; Matsoukas, J.
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2003Conformation and bioactivity: design and discovery of novel antihypertensive drugsMavromoustakos, Thomas; Zervou, Maria; Zoumpoulakis, Panagiotis; Kyrikou, I.; Roumelioti, P.; Giatas, N.; Zoga, A.; Minakakis, P.M.; Kamoutsis, C.; Dimitriou, D.; Pitsas, A.; Matsoukas, J.
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2003Design, conformation and bioactivity of novel angiotensin II receptor antagonistsMavromoustakos, Thomas; Zoumpoulakis, Panagiotis; Roumelioti, P.; Giatas, N.; Zoga, A.; Vlahakos, D.; Iliodromitis, E.; Matsoukas, J.
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2003Conformational and biological studies for a pair of novel synthetic AT(1) antagonists: stereoelectronic requirements for antihypertensive efficacyZoumpoulakis, Panagiotis; Zoga, A.; Roumelioti, P.; Giatas, N.; Grdadolnik, S. G.; Iliodromitis, E.; Vlahakos, D.; Kremastinos, D.; Matsoukas, J. M.; Mavromoustakos, Thomas
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2004Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser(42)-Phe-Leu-Leu-Arg(46) motif sequence: Platelet aggregation and relaxant activitiesAlexopoulos, K.; Fatseas, P.; Melissari, E.; Vlahakos, D.; Roumelioti, P.; Mavromoustakos, Thomas; Mihailescu, S.; Paredes-Carbajal, M. C.; Mascher, D.; Matsoukas, J.
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2004Conformation and bioactivity. Design and discovery of novel antihypertensive drugsMavromoustakos, Thomas; Zervou, Maria; Zoumpoulakis, Panagiotis; Kyrikou, I.; Benetis, N. P.; Polevaya, L.; Roumelioti, P.; Giatas, N.; Zoga, A.; Minakakis, P. M.; Kolocouris, A.; Vlahakos, D.; Grdadolnik, S. G.; Matsoukas, J.
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