Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Steroid and thyroid hormone receptors in mitochondria
Δημιουργός/Συγγραφέας:	Psarra, Anna-Maria G. [EL] Σέκερης, Κωνσταντίνος Ε.[EN] Sekeris, Constantine E.
Τόπος έκδοσης:	Malden
Ημερομηνία:	2008-04
Γλώσσα:	Αγγλικά
DOI:	10.1002/iub.37
Περίληψη:	Receptors for glucocorticoids, estrogens, androgens, and thyroid hormones have been detected in mitochondria of various cell types by Western blotting, immunofluorescence labeling, confocal microscopy, and immunogold electron microscopy. A role of these receptors in mitochondrial transcription, OXPHOS biosynthesis, and apoptosis is now being revealed. Steroid and thyroid hormones regulate energy production, inducing nuclear and mitochondrial OXPHOS genes by way of cognate receptors. In addition to the action of the nuclearly localized receptors on nuclear OXPHOS gene transcription, a parallel direct action of the mitochondrially localized receptors on mitochondrial transcription has been demonstrated. The coordination of transcription activation in nuclei and mitochondria by the respective receptors is in part realized by their binding to common trans acting elements in the two genomes. Recent evidence points to a role of the mitochondrial receptors in cell survival and apoptosis, exerted by genomic and nongenomic mechanisms. The identification of additional receptors of the superfamily of nuclear receptors and of other nuclear transcription factors in mitochondria increases their arsenal of regulatory molecules and further underlines the central role of these organelles in the integration of growth, metabolic, and cell survival signals.
Τίτλος πηγής δημοσίευσης:	Iubmb Life (formerly Biochemistry and Molecular Biology International) (no Longer Published by Taylor & Francis)
Τόμος/Κεφάλαιο:	60
Τεύχος:	4
Σελίδες:	210-223
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	steroid receptors thyroid hormone receptors mitochondria transcription OXPHOS apoptosis
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2008 IUBMB.
Όροι και προϋποθέσεις δικαιωμάτων:	Free access by the publisher. This article appears in "Iubmb Life (formerly Biochemistry and Molecular Biology International), v60, Issue , p. 210-223, 2008" and can be found at the following URL on Wiley Online Library: http://dx.doi.org/10.1002/iub.37
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://iubmb.onlinelibrary.wiley.com/journal/15216551
Σημειώσεις:	Review
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο