Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Bulky DNA Adducts in White Blood Cells: A Pooled Analysis of 3,600 Subjects
Δημιουργός/Συγγραφέας:	Ricceri, Fulvio Godschalk, Roger W. Peluso, Marco Phillips, David H. Agudo, Antonio [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis Loft, Steffen Tjonneland, Anne Raaschou-Nielsen, Ole Palli, Domenico Perera, Frederica Vermeulen, Roel Taioli, Emanuela Sram, Radim J. Munnia, Armelle Rosa, Fabio Allione, Alessandra Matullo, Giuseppe Vineis, Paolo
Εκδότης:	American Association for Cancer Research (A A C R)
Τόπος έκδοσης:	PHILADELPHIA
Ημερομηνία:	2010-12
Γλώσσα:	Αγγλικά
ISSN:	1055-9965
DOI:	10.1158/1055-9965.EPI-10-0314
Περίληψη:	Background: Bulky DNA adducts are markers of exposure to genotoxic aromatic compounds, which reflect the ability of an individual to metabolically activate carcinogens and to repair DNA damage. Polycyclic aromatic hydrocarbons (PAHs) represent a major class of carcinogens that are capable of forming such adducts. Factors that have been reported to be related to DNA adduct levels include smoking, diet, body mass index (BMI), genetic polymorphisms, the season of collection of biologic material, and air pollutants. Methods: We pooled 11 studies (3,600 subjects) in which bulky DNA adducts were measured in human white blood cells with similar (32)P-postlabeling techniques and for which a similar set of variables was available, including individual data on age, gender, ethnicity, batch, smoking habits, BMI, and season of blood collection, and a limited set of gene variants. Results: Lowest DNA adduct levels (P = 0.006) were observed in the spring (median = 0.50 adducts per 10(8) nucleotides), followed by summer (0.64), autumn (0.70), and winter (0.85). The same pattern emerged in multivariate analysis but only among never smokers (P = 0.02). Adduct levels were significantly lower (P = 0.001) in northern Europe (the Netherlands and Denmark; mean = 0.60, median = 0.40) than in southern Europe (Italy, Spain, France, and Greece; mean = 0.79, median = 0.60). Conclusions: In this large pooled analysis, we have found only weak associations between bulky DNA adducts and exposure variables. Seasonality (with higher adducts levels in winter) and air pollution may partly explain some of the interarea differences (north vs. south Europe), but most inter-area and interindividual variations in adduct levels still remain unexplained. Impact: Our study describes the largest pooled analysis of bulky DNA adducts so far, showing that interindividual variation is still largely unexplained, though seasonality seems to play a role.
Τίτλος πηγής δημοσίευσης:	Cancer Epidemiology Biomarkers & Prevention
Τόμος/Κεφάλαιο:	19
Τεύχος:	12
Σελίδες:	3174-3181
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)
Λέξεις-Κλειδιά:	Public, Environmental & Occupational Health
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2010 AACR.
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο