Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Association of Serum Brain-Derived Neurotrophic Factor and Duration of Untreated Psychosis in First-Episode Patients with Schizophrenia
Δημιουργός/Συγγραφέας:	Rizos, E. N. Michalopoulou, P. G. Siafakas, N. Stefanis, N. Douzenis, A. Rontos, I. Laskos, E. Kastania, A. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Lykouras, L.
Εκδότης:	Karger
Τόπος έκδοσης:	Basel
Ημερομηνία:	2010
Γλώσσα:	Αγγλικά
ISSN:	0302-282X
DOI:	10.1159/000315438
Περίληψη:	Background/Aims: The brain-derived neurotrophic factor (BDNF) levels in serum and the central nervous system are altered in patients with schizophrenia, suggesting that changes in the expression of BDNF might contribute to the disease pathophysiology. Long duration of untreated psychosis (DUP) has been associated with poorer prognosis in patients with schizophrenia. Such a relationship of untreated psychosis to outcome may indicate a neurodegenerative process and may have important implications for understanding the pathophysiology of schizophrenia. Methods: In this study, we investigated the association between serum BDNF levels and DUP in a sample of drug-nave patients in their first episode of schizophrenia (FEP). We investigated serum BDNF levels in a sample of 37 drug-naive FEP patients and 21 matched healthy subjects. Results: The serum BDNF level in the sample of FEP was significantly reduced compared to the healthy subjects (18.87 +/- 8.23 vs. 29.2 +/- 7.73 ng/ml, t = 4.76, d.f. = 57, p = 0.01). A negative correlation was found between serum BDNF levels and DUP in the group of patients (r = -0.346, p = 0.036). Conclusions: Our findings indicate that low serum BDNF levels at the onset of schizophrenia were associated with a long DUP and this could reflect an acute neurodegenerative reaction during the untreated phase of psychosis.
Τίτλος πηγής δημοσίευσης:	Neuropsychobiology
Τόμος/Κεφάλαιο:	62
Τεύχος:	2
Σελίδες:	87-90
Θεματική Κατηγορία:	[EL] Εσωτερική ιατρική[EN] Internal medicine [EL] Ψυχολογία[EN] Psychology
Λέξεις-Κλειδιά:	Brain-derived neurotrophic factor First episode of schizophrenia Duration of untreated psychosis Neurosciences Psychiatry Neurosciences & Neurology
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2010 S. Karger AG, Basel
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο