Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Comparison of thermal effects of stilbenoid analogs in lipid bilayers using differential scanning calorimetry and molecular dynamics: correlation of thermal effects and topographical position with antioxidant activity
Δημιουργός/Συγγραφέας:	Koukoulitsa, Catherine Durdagi, Serdar [EL] Σιάπη, Ελένη[EN] Siapi, Eleni [EL] Βιλλιαλονγκα-Μπαρμπέρ, Καρολίνα[EN] Villalonga-Barber, Carolina Alexi, Xanthippi [EL] Στηλ, Μπάρυ[EN] Steele, Barry R. [EL] Μίχα-Σκρέττα, Μαρία[EN] Micha-Screttas, Maria [EL] Αλέξης, Μιχαήλ Ν.[EN] Alexis, Michael N. Tsantili-Kakoulidou, Anna [EL] Μαυρομούστακος, Θωμάς[EN] Mavromoustakos, Thomas
Εκδότης:	Springer
Τόπος έκδοσης:	New York
Ημερομηνία:	2011-07
Γλώσσα:	Αγγλικά
ISSN:	0175-7571
DOI:	10.1007/s00249-011-0705-4
Περίληψη:	In previous studies it was shown that cannabinoids (CBs) bearing a phenolic hydroxyl group modify the thermal properties of lipid bilayers more significantly than methylated congeners. These distinct differential properties were attributed to the fact that phenolic hydroxyl groups constitute an anchoring group in the vicinity of the head-group, while the methylated analogs are embedded deeper towards the hydrophobic region of the lipid bilayers. In this work the thermal effects of synthetic polyphenolic stilbenoid analogs and their methylated congeners have been studied using differential scanning calorimetry (DSC). Molecular dynamics (MD) simulations have been performed to explain the DSC results. Thus, two of their phenolic hydroxyl groups orient in the lipid bilayers in such a way that they anchor in the region of the head-group. In contrast, their methoxy congeners cannot anchor effectively and are embedded deeper in the hydrophobic segment of the lipid bilayers. The MD results explain the fact that hydroxystilbenoid analogs exert more significant effects on the pretransition than their methoxy congeners, especially at low concentrations. To maximize the polar interactions, the two phenolic hydroxyl groups are localized in the vicinity of the head-group region, directing the remaining hydroxy group in the hydrophobic region. This topographical position of stilbenoid analogs forms a mismatch that explains the significant broadening of the width of the phase transition and lowering of the main phasetransition temperature in the lipid bilayers. At high concentrations, hydroxy and nonhydroxy analogs appear to form different domains. The correlation of thermal effects with antioxidant activity is discussed.
Τίτλος πηγής δημοσίευσης:	European Biophysics Journal with Biophysics Letters
Τόμος/Κεφάλαιο:	40
Τεύχος:	7
Σελίδες:	865-875
Θεματική Κατηγορία:	[EL] Φυσική[EN] Physics
Λέξεις-Κλειδιά:	DPPC DSC Molecular dynamics Resveratrol analogs Stilbenes Biophysics
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© SPRINGER
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.springerlink.com/openurl.asp?genre=journal&issn=0175-7571
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012) Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο