Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Diet and Expression of Estrogen Alpha and Progesterone Receptors in Malignant Mammary Tissue
Δημιουργός/Συγγραφέας:	Lagiou, Areti Samoli, Evangelia Georgila, Christina Zourna, Pantelina Barbouni, Anastasia Vassilarou, Dorothy Tsikkinis, Annivas [EL] Σέκερης, Κωνσταντίνος Ε.[EN] Sekeris, Constantine E. Trichopoulos, Dimitrios Lagiou, Pagona
Εκδότης:	Lawrence Erlbaum Association Inc-taylor & Francis
Τόπος έκδοσης:	Philadelphia
Ημερομηνία:	2011
Γλώσσα:	Αγγλικά
ISSN:	0163-5581
DOI:	10.1080/01635581.2010.516872
Περίληψη:	Estrogen receptor (ER) and/or progesterone receptor (PR) expression has been associated with more favorable breast cancer prognosis. Results on the differential association of diet with ER and/or PR positive and negative tumors have been inconclusive. In a large case-control study conducted in Athens, Greece, we investigated whether diet is associated with the expression of ERalpha or PR in mammary tumors of 421 women with histologically confirmed breast cancer. Diet was assessed through an extensive food frequency questionnaire and results were analyzed using multiple logistic regression. After controlling for non-nutritional variables and mutually adjusting for energy-generating nutrients and ethanol, carbohydrate intake was inversely associated with ER-alpha (P = 0.04) and PR (P = 0.10) expression. The odds ratios (OR) per one standard deviation increment were 0.69 with 95% confidence interval (95% CI) 0.48-0.98 for ER-alpha and 0.72 (95% CI 0.49-1.07) for PR expression. No consistent or statistically significant associations were noted for any of the other energy-generating nutrients or food groups examined. Although in these data no strong relations of qualitative aspects of diet with hormone receptor expression in breast cancer tumors were evident, the inverse association of carbohydrate intake with ERalpha, and perhaps PR, expression merits further study in future investigations.
Τίτλος πηγής δημοσίευσης:	Nutrition and Cancer-an International Journal
Τόμος/Κεφάλαιο:	63
Τεύχος:	1
Σελίδες:	65-72
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)
Λέξεις-Κλειδιά:	Nutrition & Dietetics
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο