Εξειδίκευση τύπου :	Ανακοίνωση σε συνέδριο
Τίτλος:	Delineation and interpretation of gene networks towards their effect in cellular physiology-A reverse engineering approach for the identification of critical molecular players, through the use of ontologies
Δημιουργός/Συγγραφέας:	Moutselos, K. Maglogiannis, I. [EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis
Εκδότης:	IEEE
Τόπος έκδοσης:	New York
Ημερομηνία:	2010
Γλώσσα:	Αγγλικά
ISBN:	ISBN: 978-1-4244-4124-2
ISSN:	1557-170X
DOI:	10.1109/IEMBS.2010.5626249
Περίληψη:	Exploiting ontologies, provides clues regarding the involvement of certain molecular processes in the cellular phenotypic manifestation. However, identifying individual molecular actors (genes, proteins, etc.) for targeted biological validation in a generic, prioritized, fashion, based in objective measures of their effects in the cellular physiology, remains a challenge. In this work, a new meta-analysis algorithm is proposed for the holistic interpretation of the information captured in -omic experiments, that is showcased in a transcriptomic, dynamic, DNA microarray dataset, which examines the effect of mastic oil treatment in Lewis lung carcinoma cells. Through the use of the Gene Ontology this algorithm relates genes to specific cellular pathways and vice versa in order to further reverse engineer the critical role of specific genes, starting from the results of various statistical enrichment analyses. The algorithm is able to discriminate candidate hub-genes, implying critical biochemical cross-talk. Moreover, performance measures of the algorithm are derived, when evaluated with respect to the differential expression gene list of the dataset.
Όνομα εκδήλωσης:	32nd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 10)
Ημ/νία έναρξης εκδήλωσης :	2010-08-30
Ημ/νία λήξης εκδήλωσης :	2010-09-04
Τόπος εκδήλωσης:	Buenos Aires, ARGENTINA
Τίτλος πηγής δημοσίευσης:	2010 Annual International Conference of the Ieee Engineering in Medicine and Biology Society (embc)
Σελίδες:	6709-6712
Θεματική Κατηγορία:	[EL] Μηχανική (Γενικά). Πολιτική μηχανική (Γενικά)[EN] Engineering (General). Civil engineering (General)
Λέξεις-Κλειδιά:	Engineering, Biomedical Engineering, Electrical & Electronic
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© IEEE
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο